Abstract:
Significance: The combination of hydrogel biomaterials with exosomes to facilitate wound healing and skin regeneration is a promising approach. Recent Advances: Recent preclinical animal studies have focused on investigating the efficacy of hydrogel-based delivery systems for exosomes in promoting wound healing and skin regeneration. Critical Issues: Despite encouraging results, critical issues remain unresolved, such as optimizing hydrogel properties to enhance the efficacy of combined therapy with exosomes for wound and bridging the translational gap between preclinical and clinical applications. Future Directions: Future research endeavors should concentrate on refining hydrogel design to enhance exosome delivery efficacy, conducting rigorous clinical trials to assess the safety and efficacy of exosome-loaded hydrogels in human wound healing and skin regeneration, and exploring innovative strategies to maximize therapeutic outcomes.
摘要:
结论:将水凝胶生物材料与外泌体结合以促进伤口愈合和皮肤再生是一种有前途的方法。
背景:最近的临床前动物研究集中于研究外泌体的基于水凝胶的递送系统在促进伤口愈合和皮肤再生中的功效。
结果:尽管结果令人鼓舞,关键问题仍未解决,例如,优化水凝胶的特性,以提高伤口外泌体联合治疗的功效,并弥合临床前和临床应用之间的转化差距。
结论:未来的研究工作应该集中在改进水凝胶设计,以增强外泌体递送功效,进行严格的临床试验,以评估外泌体加载水凝胶在人体伤口愈合和皮肤再生中的安全性和有效性,并探索创新策略,以最大限度地提高治疗效果。