Abstract：
p-glycoprotein (P-gp) is an efflux transporter of xenobiotic and endogenous compounds across the blood-brain barrier (BBB). P-gp plays an essential role by limiting passage of these compounds into the brain tissue. It is susceptible to drug-drug interactions when interactors drugs are co-administrated. The efficiency of P-gp may be affected by the aging process and the development of neurodegenerative diseases. Studying this protein in older adults is therefore highly relevant for all these reasons. Understanding P-gp activity in vivo is essential when considering the physiological, pathophysiological, and pharmacokinetic perspectives, as these aspects seem to be interconnected to some extent. In vivo exploration in humans is based on neuroimaging techniques, which have been improving over the last years. The advancement of exploration and diagnostic tools is opening up new prospects for understanding P-gp activity at the BBB.
摘要：
P-糖蛋白(P-gp)是跨血脑屏障(BBB)的外源性和内源性化合物的外排转运蛋白。P-gp通过限制这些化合物进入脑组织发挥重要作用。当相互作用药物共同给药时，它容易受到药物-药物相互作用的影响。P-gp的效率可能受到衰老过程和神经退行性疾病发展的影响。因此，出于所有这些原因，在老年人中研究这种蛋白质是高度相关的。了解体内P-gp活性是必不可少的，病理生理学，和药代动力学观点，因为这些方面似乎在某种程度上是相互联系的。人体的体内探索是基于神经成像技术，在过去的几年里一直在改善。探索和诊断工具的进步为了解BBB的P-gp活性开辟了新的前景。
