Abstract：
Cases of systemic lupus erythematosus (SLE) following psoriatic arthritis (PsA) or vice versa are uncommon. Due to the complexity of autoimmune diseases and the rarity of such cases, comprehensive global data on the co-occurrence of these conditions are limited. Moreover, the pathophysiology concerning the coexistence of SLE and PsA has yet to be fully understood. Interestingly, the progression of both diseases appears to be significantly influenced by the key interleukin (IL) 17, particularly IL-17A. Here, we report 7 cases of SLE and PsA coexistence. In 5 of these cases, PsA occurred before the development of SLE, while in the remaining 2 cases, SLE was diagnosed before PsA. The PsA was characterized mainly by peripheral arthritis without any axial involvement, while the manifestations of SLE varied, with 3 developing systematic severe manifestations. Therapeutic challenges were posed in all cases, as treating one condition could worsen the other. Finally, we review the literature providing the current knowledge on the coexistence of these conditions. Overall, all reported cases emphasize the importance of personalized treatment and careful monitoring for patients with both SLE and PsA.
摘要：
银屑病关节炎（PsA）后的系统性红斑狼疮（SLE）病例很少见，反之亦然。由于自身免疫性疾病的复杂性和此类病例的罕见性，关于这些条件共同发生的全面全球数据是有限的。此外，关于SLE和PsA共存的病理生理学尚未完全了解。有趣的是,两种疾病的进展似乎都受到关键白细胞介素(IL)17,特别是IL-17A的显著影响。这里,我们报告了7例SLE和PsA共存的病例。在其中5个案例中，PsA发生在SLE发展之前，而在其余的两个案例中，SLE在PsA之前诊断。PsA的特征主要是周围性关节炎，没有任何轴向受累。虽然SLE的表现多种多样，有3种正在发展的系统性严重表现。所有病例都面临治疗挑战，因为治疗一种情况会使另一种情况恶化。最后,我们回顾了提供这些条件共存的最新知识的文献。总的来说,所有报道的病例都强调对SLE和PsA患者进行个性化治疗和仔细监测的重要性.
