Abstract：
Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and whose afferents are distributed throughout the different layers of the digestive wall. The vagus nerve is a key element of the autonomic nervous system, involved in the stress response, at the interface of the microbiota-gut-brain axis, has anti-inflammatory and prokinetic properties, modulates intestinal permeability, and has a significant capacity of plasticity and regeneration. Targeting these properties of the vagus nerve, with vagus nerve stimulation (or non-stimulation/ pharmacological methods), could be of interest in the therapeutic management of enteric neuropathies.
摘要：
肠神经病的特征是肠道神经支配异常，包括肠神经系统，在其他功能障碍中诱导严重的肠道运动障碍。大部分胃肠道受迷走神经支配，其传出分支与肠神经系统有密切的联系，其传入分布在消化壁的不同层。迷走神经是自主神经系统的重要组成部分,参与应激反应，在微生物群-肠道-大脑轴的界面，具有抗炎和促动力特性，调节肠道通透性，具有显著的可塑性和再生能力。针对迷走神经的这些特性，迷走神经刺激（或非刺激/药理学方法），可能对肠神经病的治疗管理感兴趣。
