PDF(Pubmed)
Abstract：
The morbidity and mortality associated with type 2 diabetes mellitus (T2DM) have grown exponentially over the last 30 years. Together with its associated complications, the mortality rates have increased. One important complication in those living with T2DM is the acceleration of age-related cognitive decline. T2DM-induced cognitive impairment seriously affects memory, executive function, and quality of life. However, there is a lack of effective treatment for both diabetes and cognitive decline. Thus, finding novel treatments which are cheap, effective in both diabetes and cognitive impairment, are easily accessible, are needed to reduce impact on patients with diabetes and health-care systems. Carnosine, a histidine containing dipeptide, plays a protective role in cognitive diseases due to its antioxidant, anti-inflammation, and anti-glycation properties, all of which may slow the development of neurodegenerative diseases and ischemic injury. Furthermore, carnosine is also involved in regulating glucose and insulin in diabetes. Herein, we discuss the neuroprotective role of carnosine and its mechanisms in T2DM-induced cognitive impairment, which may provide a theoretical basis and evidence base to evaluate whether carnosine has therapeutic effects in alleviating cognitive dysfunction in T2DM patients.
摘要：
在过去的30年中，与2型糖尿病（T2DM）相关的发病率和死亡率呈指数增长。连同其相关的并发症，死亡率上升了。2型糖尿病患者的一个重要并发症是加速与年龄相关的认知能力下降。2型糖尿病引起的认知障碍严重影响记忆,执行功能，和生活质量。然而,对糖尿病和认知功能下降缺乏有效的治疗方法。因此，寻找便宜的新治疗方法，对糖尿病和认知障碍都有效，很容易接近，需要减少对糖尿病患者和医疗保健系统的影响。肌肽,含有组氨酸的二肽，由于其抗氧化剂在认知疾病中起着保护作用，抗炎，和抗糖基化特性，所有这些都可能减缓神经退行性疾病和缺血性损伤的发展。此外，肌肽还参与调节糖尿病的葡萄糖和胰岛素。在这里，我们讨论了肌肽在T2DM诱导的认知障碍中的神经保护作用及其机制，为评估肌肽是否有缓解T2DM患者认知功能障碍的作用提供了理论依据和证据基础。
