PDF(Pubmed)
Abstract：
With the changes of people\'s lifestyle, hyperlipidemia and hyperglycemia which were induced from a diet high in both fat and sugar have become serious health concerns. Tree peony seed oil (PSO) is a novel kind of edible oil that shows great potential in the food industry because of its high constituent of unsaturated fatty acids. Based 16S rRNA and gut untargeted metabolomics, this study elucidated that the mechanism of PSO regulating blood glucose (Glu) and lipids. The impact of PSO on gut microbiota balance and gut metabolites of mice with a high-fat diet (HFD) was evaluated. The findings indicated that PSO decreased HFD mice\'s body weight and fat accumulation, ameliorating the levels of blood lipid, reduced liver fat vacuole levels. What\'s more PSO modulated the proportion of gut microbiota in HFD mice and enhanced the abundance of probiotics. Furthermore, untargeted metabolomic analysis revealed that PSO not only impacted the generation of short-chain fatty acids (SCFAs) by gut microorganism and altered metabolic pathway but exerted influence on secondary bile acids (BA), amino acid metabolism, and various other metabolites. These results suggested that PSO has the potential function for mitigating HFD-induced hyperlipidemia and hyperglycemia by regulating gut microbiota and host metabolism.
摘要：
随着人们生活方式的改变,高脂肪和高糖饮食引起的高脂血症和高血糖已成为严重的健康问题。牡丹籽油（PSO）是一种新型的食用油，由于其不饱和脂肪酸含量高，在食品工业中显示出巨大的潜力。基于16SrRNA和肠道非靶向代谢组学，本研究阐明了PSO调节血糖（Glu）和血脂的机制。评估了PSO对具有高脂肪饮食(HFD)的小鼠的肠道微生物群平衡和肠道代谢产物的影响。结果表明，PSO降低了HFD小鼠的体重和脂肪积累，改善血脂水平，降低肝脏脂肪液泡水平。更重要的是，PSO调节了HFD小鼠肠道菌群的比例，提高了益生菌的丰度。此外，非靶向代谢组学分析显示，PSO不仅影响肠道微生物产生短链脂肪酸（SCFA），改变代谢途径，而且对次级胆汁酸（BA）产生影响，氨基酸代谢，和各种其他代谢物。这些结果表明，PSO具有通过调节肠道菌群和宿主代谢来减轻HFD诱导的高脂血症和高血糖的潜在功能。
