PDF(Pubmed)
Abstract：
UNASSIGNED: This article is an evaluation of the current trial processes within a national proton beam therapy (PBT) clinical trial service in the United Kingdom. The work within the article identifies priority challenges associated with the implementation of PBT trials with a view to improving patient trial processes.
UNASSIGNED: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question \"what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?\" Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.
UNASSIGNED: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.
UNASSIGNED: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.
UNASSIGNED: This is the first publication to evaluate current clinical trial processes for the United Kingdom\'s PBT service.
UNASSIGNED: The nominal group technique (NGT) was used. Five Clinical Trials Radiographers were asked the target question \"what are the major challenges when implementing PBT clinical trials and facilitating PBT trial-related activities?\" Participants individually and silently listed their challenges to the target question. Following this, group discussion clarified and refined responses. Participants then individually selected five challenges that they deemed most pertinent to the target question, giving a weighted score (out of 10). Individual scores were combined to provide a ranked, weighted order of challenges. Further group discussion identified improvement strategies to the highest scored challenges.
UNASSIGNED: After combining lists generated by participants, 59 challenges were identified. Group discussion eliminated 27 responses. Eighteen were merged, resulting in 14 challenges. The two challenges that ranked highest were: (i) lack of initial understanding of the responsibilities of teams and who the relevant stakeholders were, and (ii) that a national PBT service requires the provision of shared care across multi-disciplinary teams and sites. Improvement areas include the development of shared protocols, clarifying stakeholder responsibilities and improving communication between centres to streamline PBT trial processes.
UNASSIGNED: This work has identified priority areas requiring development to improve the conduct of a national PBT clinical trials programme.
UNASSIGNED: This is the first publication to evaluate current clinical trial processes for the United Kingdom\'s PBT service.
摘要：
■本文是对英国国家质子束疗法（PBT）临床试验服务中当前试验过程的评估。本文中的工作确定了与实施PBT试验相关的优先挑战，以改善患者试验过程。
■使用标称组技术(NGT)。五个临床试验放射技师被问及目标问题“实施PBT临床试验和促进PBT试验相关活动时面临的主要挑战是什么？”参与者分别和默默地列出了他们对目标问题的挑战。在此之后,小组讨论澄清和完善了答复。然后，参与者分别选择了他们认为与目标问题最相关的五个挑战，给出加权得分(满分10分)。个人得分组合以提供排名，挑战的加权顺序。进一步的小组讨论确定了针对得分最高的挑战的改进策略。
■合并参与者生成的列表后，确定了59个挑战。小组讨论取消了27项答复。18个被合并，造成14项挑战。排名最高的两个挑战是：（i）对团队的责任以及相关利益相关者是谁缺乏初步了解，（ii）国家PBT服务要求跨多学科团队和站点提供共享护理。改进领域包括开发共享协议，明确利益相关方的责任并改善中心之间的沟通，以简化PBT试验流程。
■这项工作确定了需要开发的优先领域，以改善国家PBT临床试验计划的开展。
■这是第一份评估英国PBT服务当前临床试验流程的出版物。
■使用标称组技术(NGT)。五个临床试验放射技师被问及目标问题“实施PBT临床试验和促进PBT试验相关活动时面临的主要挑战是什么？”参与者分别和默默地列出了他们对目标问题的挑战。在此之后,小组讨论澄清和完善了答复。然后，参与者分别选择了他们认为与目标问题最相关的五个挑战，给出加权得分(满分10分)。个人得分组合以提供排名，挑战的加权顺序。进一步的小组讨论确定了针对得分最高的挑战的改进策略。
■合并参与者生成的列表后，确定了59个挑战。小组讨论取消了27项答复。18个被合并，造成14项挑战。排名最高的两个挑战是：（i）对团队的责任以及相关利益相关者是谁缺乏初步了解，（ii）国家PBT服务要求跨多学科团队和站点提供共享护理。改进领域包括开发共享协议，明确利益相关方的责任并改善中心之间的沟通，以简化PBT试验流程。
■这项工作确定了需要开发的优先领域，以改善国家PBT临床试验计划的开展。
■这是第一份评估英国PBT服务当前临床试验流程的出版物。
