PDF(Pubmed)
Abstract：
Aortic aneurysm and dissection (AAD) are severe vascular diseases with high mortality rates. However, the causal relationship between serum uric acid levels and the occurrence of AAD remains a subject of controversy. To address this issue, we conducted a two-sample Mendelian randomization (MR) analysis to investigate whether there is a causal association between these factors. We obtained single-nucleotide polymorphisms (SNPs) data related to serum uric acid levels from the FinnGen study and data on AAD from the UK Biobank. Various two-sample MR methods, including inverse variance weighted (IVW) analysis, MR-Egger regression analysis, weighted median analysis, and contamination mixture method, were employed to assess the causal relationship between serum uric acid and the risk of AAD. Sensitivity analysis was conducted to evaluate the stability and reliability of the results. The findings revealed a positive association between serum uric acid levels and the risk of aortic aneurysm (AA) (odds ratio [OR] = 1.200, 95 % confidence interval [CI]: 1.020-1.400, P = 0.0239). However, no significant correlation was observed between serum uric acid levels and the occurrence of aortic dissection (AD) (OR = 0.893, 95 % CI = 0.602-1.326, P = 0.576). Our study, which employed MR analysis, identified a positive association between serum uric acid levels and the risk of AA. However, we did not observe a significant correlation with AD.
摘要：
主动脉瘤和夹层（AAD）是严重的血管疾病，死亡率很高。然而,血尿酸水平与AAD发生之间的因果关系仍存在争议。为了解决这个问题，我们进行了双样本孟德尔随机化(MR)分析,以调查这些因素之间是否存在因果关系.我们从FinnGen研究中获得了与血清尿酸水平相关的单核苷酸多态性（SNP）数据，并从UKBiobank获得了AAD数据。各种双样本MR方法，包括逆方差加权(IVW)分析，MR-Egger回归分析，加权中位数分析，和污染混合方法，用于评估血清尿酸与AAD风险之间的因果关系。进行了敏感性分析，以评估结果的稳定性和可靠性。研究结果表明，血清尿酸水平与主动脉瘤（AA）的风险之间存在正相关（比值比[OR]=1.200，95％置信区间[CI]：1.020-1.400，P=0.0239）。然而,血清尿酸水平与主动脉夹层（AD）的发生无明显相关性（OR=0.893，95％CI=0.602-1.326，P=0.576）。我们的研究,采用MR分析，确定血清尿酸水平与AA风险之间呈正相关。然而,我们没有观察到与AD的显著相关性。
