PDF(Pubmed)
Abstract：
UNASSIGNED: The systemic immune-inflammation index (SII) showed an extensive link between immunological dysfunction and the activation of systemic inflammation. Several studies have confirmed the application of SII to orthopedic diseases. However, the significance of SII in critically ill elderly individuals with hip fracture who require intensive care unit (ICU) admission is not yet known. This study centered on exploring the relationship between SII and clinical outcomes among critically ill elderly hip fracture individuals.
UNASSIGNED: The study centered around elderly patients experiencing severe illness following hip fractures and requiring admission to the ICU. These patients from the MIMIC-IV database formed the basis of this study\'s cohort. We stratified them into quartiles according to their SII levels. The results involved the mortality at 30 days and 1 year post-admission. Then we employ Cox proportional hazards regression analysis as well as restricted cubic splines to explore the association between the SII and clinical results in critically ill elderly patients with hip fracture.
UNASSIGNED: The study encompassed 991 participants, among whom 63.98% identified as females. Notably, the mortality rates attributed to any cause within 30 days and 1 year after hospitalization stood at 19.68 and 33.40%, respectively. The multivariate Cox proportional hazards model disclosed a significant correlation between an elevated SII and all-cause mortality. Following adjustments for confounding variables, individuals with a high SII showed a notable correlation with 30-day mortality [adjusted hazard ratio (HR), 1.065; 95% confidence interval (CI), 1.044-1.087; p < 0.001] and 1-year mortality (adjusted HR, 1.051; 95% CI, 1.029-1.074; p < 0.001). Furthermore, the analysis of restricted cubic splines demonstrated a progressive increase in the risk of all-cause death as the SII value rose.
UNASSIGNED: Among critically ill elderly patients with hip fracture, the SII exhibits a non-linear association that positively correlates with both 30-day and 1-year all-cause mortality rates. The revelation indicates that the SII may play a vital role in identifying patients with hip fractures who face an escalated risk of mortality due to any cause.
UNASSIGNED: The study centered around elderly patients experiencing severe illness following hip fractures and requiring admission to the ICU. These patients from the MIMIC-IV database formed the basis of this study\'s cohort. We stratified them into quartiles according to their SII levels. The results involved the mortality at 30 days and 1 year post-admission. Then we employ Cox proportional hazards regression analysis as well as restricted cubic splines to explore the association between the SII and clinical results in critically ill elderly patients with hip fracture.
UNASSIGNED: The study encompassed 991 participants, among whom 63.98% identified as females. Notably, the mortality rates attributed to any cause within 30 days and 1 year after hospitalization stood at 19.68 and 33.40%, respectively. The multivariate Cox proportional hazards model disclosed a significant correlation between an elevated SII and all-cause mortality. Following adjustments for confounding variables, individuals with a high SII showed a notable correlation with 30-day mortality [adjusted hazard ratio (HR), 1.065; 95% confidence interval (CI), 1.044-1.087; p < 0.001] and 1-year mortality (adjusted HR, 1.051; 95% CI, 1.029-1.074; p < 0.001). Furthermore, the analysis of restricted cubic splines demonstrated a progressive increase in the risk of all-cause death as the SII value rose.
UNASSIGNED: Among critically ill elderly patients with hip fracture, the SII exhibits a non-linear association that positively correlates with both 30-day and 1-year all-cause mortality rates. The revelation indicates that the SII may play a vital role in identifying patients with hip fractures who face an escalated risk of mortality due to any cause.
摘要：
■全身免疫炎症指数（SII）显示免疫功能障碍与全身炎症的激活之间存在广泛的联系。一些研究证实了SII在骨科疾病中的应用。然而,SII在需要入住重症监护病房(ICU)的髋部骨折危重老年患者中的意义尚不清楚.本研究旨在探讨老年髋部骨折患者SII与临床预后的关系。
这项研究集中在髋部骨折后患有严重疾病并需要进入ICU的老年患者。这些来自MIMIC-IV数据库的患者构成了本研究队列的基础。我们根据它们的SII水平将它们分层为四分位数。结果涉及入院后30天和1年的死亡率。然后，我们使用Cox比例风险回归分析以及有限的三次样条来探索SII与重症老年髋部骨折患者临床结果之间的关联。
■该研究包括991名参与者，其中63.98%为女性。值得注意的是,住院后30天内和1年内归因于任何原因的死亡率分别为19.68％和33.40％，分别。多变量Cox比例风险模型揭示了SII升高与全因死亡率之间的显着相关性。在对混杂变量进行调整之后，具有高SII的个体显示出与30天死亡率[调整后的风险比（HR），1.065；95%置信区间(CI)，1.044-1.087；p<0.001]和1年死亡率(调整后的HR，1.051；95%CI，1.029-1.074；p<0.001)。此外，限制性三次样条分析显示,随着SII值的升高,全因死亡风险逐渐增加.
■在老年髋部骨折危重患者中，SII显示出与30日和1年全因死亡率呈正相关的非线性关联.该发现表明，SII可能在识别因任何原因面临死亡风险升高的髋部骨折患者中起着至关重要的作用。
这项研究集中在髋部骨折后患有严重疾病并需要进入ICU的老年患者。这些来自MIMIC-IV数据库的患者构成了本研究队列的基础。我们根据它们的SII水平将它们分层为四分位数。结果涉及入院后30天和1年的死亡率。然后，我们使用Cox比例风险回归分析以及有限的三次样条来探索SII与重症老年髋部骨折患者临床结果之间的关联。
■该研究包括991名参与者，其中63.98%为女性。值得注意的是,住院后30天内和1年内归因于任何原因的死亡率分别为19.68％和33.40％，分别。多变量Cox比例风险模型揭示了SII升高与全因死亡率之间的显着相关性。在对混杂变量进行调整之后，具有高SII的个体显示出与30天死亡率[调整后的风险比（HR），1.065；95%置信区间(CI)，1.044-1.087；p<0.001]和1年死亡率(调整后的HR，1.051；95%CI，1.029-1.074；p<0.001)。此外，限制性三次样条分析显示,随着SII值的升高,全因死亡风险逐渐增加.
■在老年髋部骨折危重患者中，SII显示出与30日和1年全因死亡率呈正相关的非线性关联.该发现表明，SII可能在识别因任何原因面临死亡风险升高的髋部骨折患者中起着至关重要的作用。
