PDF(Pubmed)
Abstract：
Squamous papilloma is a benign neoplasm that originates from the stratified squamous epithelium of the mucous membrane. Its principal etiological factor is human papillomavirus infection, with a predilection for manifesting within the oral cavity. Squamous papilloma predominantly affects regions on the palate, cheeks, lips and tongue. However, to the best of our knowledge, the occurrence of squamous papilloma within the confines of the mandible remains unreported hitherto. The present report documents a case of squamous papilloma involving the mandible who was managed at the First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) in January 2023. The patient underwent a series of recurrent jaw inflammations, manifesting with malignant imaging characteristics. Subsequent pathological analysis confirmed a diagnosis of papilloma in the jaw. The present report highlights the pivotal role of prolonged inflammation in the genesis of jaw squamous papilloma, prompting avenues for further investigation, including the potential of inflammation to induce aberrant cell growth, mediate cell interactions, orchestrate cytokine actions and influence stress mediators. In addition, the current study posits a plausible connection between persistent inflammation, compromised epithelial integrity and an increased likelihood of head and neck papilloma, particularly concerning human papillomavirus infection. This article delineates the clinical attributes of the uncommon manifestations of jaw papilloma and delves into the associated mechanisms, thereby contributing to an enhanced comprehension of jaw disorders. This comprehensive insight equips clinicians with a heightened knowledge base for more precise diagnosis and treatment of analogous cases.
摘要：
鳞状乳头状瘤是一种良性肿瘤，起源于粘膜的复层鳞状上皮。其主要病因是人乳头瘤病毒感染，倾向于在口腔内显现。鳞状乳头状瘤主要影响腭上的区域，脸颊,嘴唇和舌头然而,据我们所知,迄今为止，下颌骨范围内鳞状乳头状瘤的发生尚未报道。本报告记录了在中山大学附属第一医院治疗的一例涉及下颌骨的鳞状乳头状瘤（广州，中国）2023年1月。病人经历了一系列复发性的颌骨炎症,表现为恶性影像学特征。随后的病理分析证实了颌骨乳头状瘤的诊断。本报告强调了长期炎症在颌骨鳞状乳头状瘤发生中的关键作用，为进一步调查提供了途径，包括炎症诱导异常细胞生长的潜力，介导细胞相互作用，协调细胞因子的作用和影响应激介质。此外,目前的研究认为，持续性炎症之间存在着一种似是而非的联系，上皮完整性受损，头颈部乳头状瘤的可能性增加，特别是关于人乳头瘤病毒感染。本文描述了颌骨乳头状瘤的罕见表现的临床属性，并深入研究了相关机制。从而有助于增强对颌骨疾病的理解。这种全面的见解为临床医生提供了更高的知识库，以更精确地诊断和治疗类似病例。
