PDF(Pubmed)
Abstract：
UNASSIGNED: Inflammation contributes to the development of metabolic bone diseases. The C-reactive protein-to-albumin ratio (CAR) is an inflammation-based marker with a prognostic value for several metabolic diseases. This study investigated the relationship between the CAR and osteoporosis (OP) in patients with primary biliary cholangitis (PBC).
UNASSIGNED: Patients with PBC treated at Beijing Ditan Hospital between January 2018 and June 2023 were enrolled. Logistic regression analysis was performed to investigate the factors influencing OP. The predictive value of CAR for OP was evaluated using receiver operating characteristic (ROC) curves. Moreover, a restricted cubic spline (RCS) fitted with a logistic regression model was used to analyze the relationship between CAR and OP.
UNASSIGNED: The prevalence of OP among the patients with PBC was 26.9% (n = 82). CAR levels were higher in the OP group than in the non-OP group (0.33 (0.09, 0.61) vs. 0.08 (0.04, 0.18), P < 0.001). Logistic regression analysis showed that CAR was an independent predictor of OP in patients with PBC (odds ratio = 2.642, 95% confidence interval = 1.537-4.540, P < 0.001). CAR exhibited a good predictive ability for OP, with an areas under the curve (AUC) of 0.741. We found that individuals with CAR values > 0.1 have higher odds of OP. In addition, high CAR levels were associated with an increased prevalence of fragility fractures and high 10-year fracture risk.
UNASSIGNED: High CAR levels were associated with greater odds of developing OP, and the CAR could serve as an independent predictor of OP in patients with PBC.
UNASSIGNED: Patients with PBC treated at Beijing Ditan Hospital between January 2018 and June 2023 were enrolled. Logistic regression analysis was performed to investigate the factors influencing OP. The predictive value of CAR for OP was evaluated using receiver operating characteristic (ROC) curves. Moreover, a restricted cubic spline (RCS) fitted with a logistic regression model was used to analyze the relationship between CAR and OP.
UNASSIGNED: The prevalence of OP among the patients with PBC was 26.9% (n = 82). CAR levels were higher in the OP group than in the non-OP group (0.33 (0.09, 0.61) vs. 0.08 (0.04, 0.18), P < 0.001). Logistic regression analysis showed that CAR was an independent predictor of OP in patients with PBC (odds ratio = 2.642, 95% confidence interval = 1.537-4.540, P < 0.001). CAR exhibited a good predictive ability for OP, with an areas under the curve (AUC) of 0.741. We found that individuals with CAR values > 0.1 have higher odds of OP. In addition, high CAR levels were associated with an increased prevalence of fragility fractures and high 10-year fracture risk.
UNASSIGNED: High CAR levels were associated with greater odds of developing OP, and the CAR could serve as an independent predictor of OP in patients with PBC.
摘要：
■炎症有助于代谢性骨疾病的发展。C反应蛋白与白蛋白之比（CAR）是一种基于炎症的标志物，对几种代谢疾病具有预后价值。这项研究调查了原发性胆汁性胆管炎（PBC）患者的CAR与骨质疏松症（OP）之间的关系。
■纳入2018年1月至2023年6月在北京地坛医院接受治疗的PBC患者。采用Logistic回归分析探讨OP的影响因素。使用受试者工作特征（ROC）曲线评估CAR对OP的预测值。此外，使用符合逻辑回归模型的约束三次样条(RCS)分析CAR与OP之间的关系.
■PBC患者中OP的患病率为26.9%(n=82)。OP组的CAR水平高于非OP组（0.33（0.09，0.61）与0.08(0.04,0.18),P<0.001)。Logistic回归分析显示,CAR是PBC患者OP的独立预测因子(比值比=2.642,95%置信区间=1.537~4.540,P<0.001)。CAR对OP表现出良好的预测能力，曲线下面积（AUC）为0.741。我们发现CAR值>0.1的个体有更高的OP几率。此外,高CAR水平与脆性骨折患病率增加和高10年骨折风险相关.
■高CAR水平与发生OP的几率更大相关，CAR可以作为PBC患者OP的独立预测因子。
■纳入2018年1月至2023年6月在北京地坛医院接受治疗的PBC患者。采用Logistic回归分析探讨OP的影响因素。使用受试者工作特征（ROC）曲线评估CAR对OP的预测值。此外，使用符合逻辑回归模型的约束三次样条(RCS)分析CAR与OP之间的关系.
■PBC患者中OP的患病率为26.9%(n=82)。OP组的CAR水平高于非OP组（0.33（0.09，0.61）与0.08(0.04,0.18),P<0.001)。Logistic回归分析显示,CAR是PBC患者OP的独立预测因子(比值比=2.642,95%置信区间=1.537~4.540,P<0.001)。CAR对OP表现出良好的预测能力，曲线下面积（AUC）为0.741。我们发现CAR值>0.1的个体有更高的OP几率。此外,高CAR水平与脆性骨折患病率增加和高10年骨折风险相关.
■高CAR水平与发生OP的几率更大相关，CAR可以作为PBC患者OP的独立预测因子。
