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Abstract：
Chronic inflammatory enteropathies (CIEs) are an important group of diseases in dogs and involve complex pathogenetic aspects. Endoscopy and histopathology are vital for documenting the disease but are less useful for subclassifying CIEs and predicting the response to treatment. However, healing of the mucosal disease process (deep remission) and ultrastructural evaluation of the mucosa have received little attention in canine CIE. Given that canine CIE shares many similarities with inflammatory bowel diseases (IBDs) in human patients-and presents a good spontaneous disease model for human IBD-this perspective article evaluates the literature on ultrastructural lesions in canine CIE and human IBD and offers future directions for the study of ultrastructural mucosal lesions in canine CIE. Such lesions might have a higher sensitivity of detection than structural changes revealed upon light microscopy and may even precede or remain after the resolution of the clinical signs and histologic lesions.
摘要：
慢性炎症性肠病（CIEs）是狗的一类重要疾病，涉及复杂的致病方面。内窥镜检查和组织病理学对于记录疾病至关重要，但对于CIEs的亚分类和预测对治疗的反应却不太有用。然而,在canineCIE中，粘膜疾病过程的愈合（深度缓解）和粘膜的超微结构评估很少受到关注。鉴于canineCIE与人类患者的炎症性肠病（IBD）有许多相似之处，并为人类IBD提供了良好的自发性疾病模型，因此本文对canineCIE和人类IBD的超微结构病变的文献进行了评估，并为研究canineCIE的超微结构粘膜病变提供了未来的方向。与光学显微镜下显示的结构变化相比，此类病变的检测灵敏度可能更高，甚至可能在临床体征和组织学病变解决后出现或保留。
