PDF(Pubmed)
Abstract：
UNASSIGNED: Observational studies have reported inconsistent results on the relationship between chronic kidney disease (CKD) and age-related macular degeneration (AMD). The primary objective of this study was to investigate the causal relationships between estimated glomerular filtration rate (eGFR), CKD, its common causes, and AMD among participants of European descent.
UNASSIGNED: Genetic variants associated with eGFR, CKD and its common causes, encompassing diabetic nephropathy (DN), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN) were obtained from previously published genome-wide association studies (GWAS) and FinnGen database. Summary statistics for early AMD, AMD, dry AMD, and wet AMD were acquired from the GWAS and FinnGen database. Inverse-variance-weighted (IVW) method was the main MR analysis. Sensitivity analyses were performed with Cochran\'s Q, MR-Egger intercept, and leave-one-out analysis. In addition, RadialMR was utilized to identify and remove outliers.
UNASSIGNED: IVW results showed that CKD, eGFR were not associated with any type of AMD (p > 0.05). DN (OR: 1.042, 95% CI: 1.002-1.083, p = 0.037) and MN (OR: 1.023, 95% CI: 1.007-1.040, p = 0.005) were associated with an increased risk of earl AMD. DN (OR: 1.111, 95% CI: 1.07-1.154, p = 4.87 × 10-8), IgAN (OR: 1.373, 95% CI: 1.097-1.719, p = 0.006), and MN (OR: 1.036, 95% CI: 1.008-1.064, p = 0.012) were associated with an increased risk of AMD. DN (OR: 1.090, 95% CI: 1.042-1.140, p = 1.57 × 10-4) and IgAN (OR: 1.480, 95% CI: 1.178-1.858, p = 7.55 × 10-4) were associated with an increased risk of dry AMD. The risk of wet AMD was associated with DN (OR: 1.107, 95% CI: 1.043-1.174, p = 7.56 × 10-4) and MN (OR: 1.071, 95% CI: 1.040-1.103, p = 5.48 × 10-6).
UNASSIGNED: This MR study found no evidence of causal relationship between CKD and AMD. DN, IgAN, and MN may increase risk of AMD. This findings underscore the importance of ocular examinations in patients with DN, MN, and IgAN. More studies are needed to support the findings of our current study.
UNASSIGNED: Genetic variants associated with eGFR, CKD and its common causes, encompassing diabetic nephropathy (DN), immunoglobulin A nephropathy (IgAN), and membranous nephropathy (MN) were obtained from previously published genome-wide association studies (GWAS) and FinnGen database. Summary statistics for early AMD, AMD, dry AMD, and wet AMD were acquired from the GWAS and FinnGen database. Inverse-variance-weighted (IVW) method was the main MR analysis. Sensitivity analyses were performed with Cochran\'s Q, MR-Egger intercept, and leave-one-out analysis. In addition, RadialMR was utilized to identify and remove outliers.
UNASSIGNED: IVW results showed that CKD, eGFR were not associated with any type of AMD (p > 0.05). DN (OR: 1.042, 95% CI: 1.002-1.083, p = 0.037) and MN (OR: 1.023, 95% CI: 1.007-1.040, p = 0.005) were associated with an increased risk of earl AMD. DN (OR: 1.111, 95% CI: 1.07-1.154, p = 4.87 × 10-8), IgAN (OR: 1.373, 95% CI: 1.097-1.719, p = 0.006), and MN (OR: 1.036, 95% CI: 1.008-1.064, p = 0.012) were associated with an increased risk of AMD. DN (OR: 1.090, 95% CI: 1.042-1.140, p = 1.57 × 10-4) and IgAN (OR: 1.480, 95% CI: 1.178-1.858, p = 7.55 × 10-4) were associated with an increased risk of dry AMD. The risk of wet AMD was associated with DN (OR: 1.107, 95% CI: 1.043-1.174, p = 7.56 × 10-4) and MN (OR: 1.071, 95% CI: 1.040-1.103, p = 5.48 × 10-6).
UNASSIGNED: This MR study found no evidence of causal relationship between CKD and AMD. DN, IgAN, and MN may increase risk of AMD. This findings underscore the importance of ocular examinations in patients with DN, MN, and IgAN. More studies are needed to support the findings of our current study.
摘要：
■观察性研究报告了关于慢性肾脏疾病（CKD）与年龄相关性黄斑变性（AMD）之间关系的不一致结果。这项研究的主要目的是调查估计的肾小球滤过率（eGFR）之间的因果关系，CKD,其共同原因,和AMD在欧洲血统的参与者中。
■与eGFR相关的遗传变异，CKD及其常见原因，包括糖尿病肾病（DN），免疫球蛋白A肾病（IgAN），和膜性肾病(MN)均来自先前发表的全基因组关联研究(GWAS)和FinnGen数据库。早期AMD的统计摘要，AMD,干性AMD,和湿性AMD从GWAS和FinnGen数据库获得。逆方差加权（IVW）方法是主要的MR分析。用Cochran'sQ进行敏感性分析，MR-Egger截获,和遗漏分析。此外,RadialMR用于识别和去除异常值。
■IVW结果表明，CKD，eGFR与任何类型的AMD均无相关性(p>0.05)。DN（OR：1.042，95％CI：1.002-1.083，p=0.037）和MN（OR：1.023，95％CI：1.007-1.040，p=0.005）与AMD的风险增加相关。DN（OR：1.111，95%CI：1.07-1.154，p=4.87×10-8），IgAN（OR：1.373，95%CI：1.097-1.719，p=0.006），和MN（OR：1.036，95％CI：1.008-1.064，p=0.012）与AMD风险增加相关。DN（OR：1.090，95％CI：1.042-1.140，p=1.57×10-4）和IgAN（OR：1.480，95％CI：1.178-1.858，p=7.55×10-4）与干性AMD的风险增加有关。湿性AMD的风险与DN（OR：1.107，95％CI：1.043-1.174，p=7.56×10-4）和MN（OR：1.071，95％CI：1.040-1.103，p=5.48×10-6）相关。
■这项MR研究没有发现CKD和AMD之间因果关系的证据。DN,伊根,和MN可能增加AMD的风险。这一发现强调了DN患者眼部检查的重要性。MN,还有Igan.需要更多的研究来支持我们当前研究的发现。
■与eGFR相关的遗传变异，CKD及其常见原因，包括糖尿病肾病（DN），免疫球蛋白A肾病（IgAN），和膜性肾病(MN)均来自先前发表的全基因组关联研究(GWAS)和FinnGen数据库。早期AMD的统计摘要，AMD,干性AMD,和湿性AMD从GWAS和FinnGen数据库获得。逆方差加权（IVW）方法是主要的MR分析。用Cochran'sQ进行敏感性分析，MR-Egger截获,和遗漏分析。此外,RadialMR用于识别和去除异常值。
■IVW结果表明，CKD，eGFR与任何类型的AMD均无相关性(p>0.05)。DN（OR：1.042，95％CI：1.002-1.083，p=0.037）和MN（OR：1.023，95％CI：1.007-1.040，p=0.005）与AMD的风险增加相关。DN（OR：1.111，95%CI：1.07-1.154，p=4.87×10-8），IgAN（OR：1.373，95%CI：1.097-1.719，p=0.006），和MN（OR：1.036，95％CI：1.008-1.064，p=0.012）与AMD风险增加相关。DN（OR：1.090，95％CI：1.042-1.140，p=1.57×10-4）和IgAN（OR：1.480，95％CI：1.178-1.858，p=7.55×10-4）与干性AMD的风险增加有关。湿性AMD的风险与DN（OR：1.107，95％CI：1.043-1.174，p=7.56×10-4）和MN（OR：1.071，95％CI：1.040-1.103，p=5.48×10-6）相关。
■这项MR研究没有发现CKD和AMD之间因果关系的证据。DN,伊根,和MN可能增加AMD的风险。这一发现强调了DN患者眼部检查的重要性。MN,还有Igan.需要更多的研究来支持我们当前研究的发现。
