Abstract：
OBJECTIVE: A more restrictive blood donation criterion has been applied in Japan, with a maximum volume of whole blood (WB) donation of 400 mL, allowing twice a year for female donors and thrice a year for male donors. However, iron deficiency was as high as 20.5% among female donors prior to donation, increasing to 37.7% after blood donation. More than 20 years have passed since then, so we set out to investigate the present situation.
METHODS: A total of 2659 (male/female: 1496/1163) donors of 400 mL WB who gave informed consent to join the study were enrolled. Serum ferritin (sFer) of first-time/reactivated (FT/RA) donors were compared with those of repeat donors, according to gender and age; those who returned for subsequent donations during the study period were also followed up.
RESULTS: About one-third of FT/RA female donors had iron deficiency, possibly reflecting its high incidence among the general population. Interestingly, although sFer levels were low among pre-menopausal FT/RA female donors, these values were not much different in repeat donors, whereas significant differences were observed between FT/RA and repeat donors among post-menopausal females and in most age groups among males. As expected, donors with a normal initial sFer (≥26 ng/mL) recovered faster than those with a low initial sFer.
CONCLUSIONS: Female donors, especially, have iron deficiency even before donation, and the rate increased compared to what was found previously. Measures to prevent iron deficiency of blood donors is required, and studies are going on in Japan.
METHODS: A total of 2659 (male/female: 1496/1163) donors of 400 mL WB who gave informed consent to join the study were enrolled. Serum ferritin (sFer) of first-time/reactivated (FT/RA) donors were compared with those of repeat donors, according to gender and age; those who returned for subsequent donations during the study period were also followed up.
RESULTS: About one-third of FT/RA female donors had iron deficiency, possibly reflecting its high incidence among the general population. Interestingly, although sFer levels were low among pre-menopausal FT/RA female donors, these values were not much different in repeat donors, whereas significant differences were observed between FT/RA and repeat donors among post-menopausal females and in most age groups among males. As expected, donors with a normal initial sFer (≥26 ng/mL) recovered faster than those with a low initial sFer.
CONCLUSIONS: Female donors, especially, have iron deficiency even before donation, and the rate increased compared to what was found previously. Measures to prevent iron deficiency of blood donors is required, and studies are going on in Japan.
摘要：
目的：日本采用了更严格的献血标准，最大全血（WB）捐献量为400毫升，允许女性捐赠者一年两次，男性捐赠者一年三次。然而,在捐赠前，女性捐赠者缺铁率高达20.5%，献血后增加到37.7%。20多年过去了，所以我们着手调查目前的情况。
方法：共有2659名（男/女：1496/1163）400mLWB患者知情同意加入本研究。将首次/再激活（FT/RA）供体的血清铁蛋白（sFer）与重复供体的血清铁蛋白（sFer）进行比较，根据性别和年龄;那些在研究期间为后续捐赠而返回的人也进行了随访。
结果：大约三分之一的FT/RA女性捐献者缺铁，可能反映了其在普通人群中的高发病率。有趣的是,尽管绝经前FT/RA女性捐献者的sFer水平较低，这些值在重复捐赠者中没有太大差异，而在绝经后女性和大多数年龄组的男性中,FT/RA和重复供者之间存在显著差异.不出所料,初始sFer正常（≥26ng/mL）的供体比初始sFer低的供体恢复更快。
结论：女性捐赠者，尤其是,甚至在捐赠之前就缺铁，与以前发现的相比，比率增加了。需要采取措施防止献血者缺铁,日本正在进行研究。
方法：共有2659名（男/女：1496/1163）400mLWB患者知情同意加入本研究。将首次/再激活（FT/RA）供体的血清铁蛋白（sFer）与重复供体的血清铁蛋白（sFer）进行比较，根据性别和年龄;那些在研究期间为后续捐赠而返回的人也进行了随访。
结果：大约三分之一的FT/RA女性捐献者缺铁，可能反映了其在普通人群中的高发病率。有趣的是,尽管绝经前FT/RA女性捐献者的sFer水平较低，这些值在重复捐赠者中没有太大差异，而在绝经后女性和大多数年龄组的男性中,FT/RA和重复供者之间存在显著差异.不出所料,初始sFer正常（≥26ng/mL）的供体比初始sFer低的供体恢复更快。
结论：女性捐赠者，尤其是,甚至在捐赠之前就缺铁，与以前发现的相比，比率增加了。需要采取措施防止献血者缺铁,日本正在进行研究。
