PDF(Pubmed)
Abstract：
BACKGROUND: TAFRO syndrome is a rare disorder that causes thrombocytopenia, generalized oedema, fever, organ enlargement, and renal impairment. Few reports have suggested an association with vaccines, and few cases have undergone renal biopsy. TAFRO syndrome is often severe and fatal, and its cause is unknown. We report a case of TAFRO syndrome that occurred after vaccination with the coronavirus disease 2019 (COVID-19) vaccine.
METHODS: An 82-year-old woman received two doses of the BNT162b2 mRNA vaccine 3 weeks apart. Two weeks later, she was admitted to the hospital with oedema, accompanied with renal failure and thrombocytopenia. After close examination, she was diagnosed with TAFRO syndrome. She was treated with steroids, cyclosporine, and thrombopoietin receptor agonists. The patient was discharged after several months in remission.
CONCLUSIONS: Although an incident of TAFRO syndrome after COVID-19 vaccination has been previously reported, this is a rare case in which the patient went into remission and was discharged. A renal biopsy was also performed in this case, which was consistent with previous reports. The favorable treatment course for TAFRO syndrome provides valuable insights.
METHODS: An 82-year-old woman received two doses of the BNT162b2 mRNA vaccine 3 weeks apart. Two weeks later, she was admitted to the hospital with oedema, accompanied with renal failure and thrombocytopenia. After close examination, she was diagnosed with TAFRO syndrome. She was treated with steroids, cyclosporine, and thrombopoietin receptor agonists. The patient was discharged after several months in remission.
CONCLUSIONS: Although an incident of TAFRO syndrome after COVID-19 vaccination has been previously reported, this is a rare case in which the patient went into remission and was discharged. A renal biopsy was also performed in this case, which was consistent with previous reports. The favorable treatment course for TAFRO syndrome provides valuable insights.
摘要：
背景：TAFRO综合征是一种引起血小板减少症的罕见疾病，全身性水肿,发烧,器官增大,和肾功能损害。很少有报告表明与疫苗有关，少数病例接受了肾活检。TAFRO综合征通常是严重和致命的，原因不明.我们报告了一例在接种2019年冠状病毒病（COVID-19）疫苗后发生的TAFRO综合征。
方法：一名82岁女性每隔3周接受两剂BNT162b2mRNA疫苗。两周后,她因水肿入院,伴有肾功能衰竭和血小板减少症。仔细检查后，她被诊断为TAFRO综合征。她接受了类固醇治疗，环孢菌素,和血小板生成素受体激动剂。患者在缓解数月后出院。
结论：尽管先前有报道称接种COVID-19后发生TAFRO综合征，这是一个罕见的病例，患者病情缓解并出院。在这种情况下还进行了肾活检，这与以前的报告一致。TAFRO综合征的良好治疗过程提供了有价值的见解。
方法：一名82岁女性每隔3周接受两剂BNT162b2mRNA疫苗。两周后,她因水肿入院,伴有肾功能衰竭和血小板减少症。仔细检查后，她被诊断为TAFRO综合征。她接受了类固醇治疗，环孢菌素,和血小板生成素受体激动剂。患者在缓解数月后出院。
结论：尽管先前有报道称接种COVID-19后发生TAFRO综合征，这是一个罕见的病例，患者病情缓解并出院。在这种情况下还进行了肾活检，这与以前的报告一致。TAFRO综合征的良好治疗过程提供了有价值的见解。
