Abstract：
While functional endoscopic evaluation of swallowing (FEES) is the most useful diagnostic test for the evaluation of dysphagia, it cannot evaluate the esophageal phase of swallowing. To evaluate if a modification for the FEES exam by swallowing an empty capsule and screening of the upper esophagus could be used for early detection of esophageal dysphagia. A prospective, single-center, pilot study. At the end of a standard FEES exam, the patients were asked to swallow an empty capsule. Fifteen seconds later, the endoscope was inserted into the upper esophagus. A pathological capsule test was defined when the capsule was seen in the esophagus. In such cases, the patient was advised to undergo a gastroscopy, MBS, or esophageal manometry, which were compared to the results of the capsule test. The capsule test was utilized in 109 patients. A pathological capsule test was found in 55 patients (57.8%). In 48 patients (87.3%), an isolated or combined esophageal dysphagia was seen. The accuracy value of the capsule test compared to gastroenterology tests was 83.3%, sensitivity 88.46%, specificity 75%, PPV 85%, and NPV 80%. A modification of the standard FEES exam by including an empty capsule swallow test with an upper esophagus examination may provide a useful screening tool for esophageal dysphagia.
摘要：
虽然吞咽功能内窥镜评估（FEES）是评估吞咽困难最有用的诊断测试，它不能评估吞咽的食道阶段。为了评估是否可以通过吞咽空胶囊和上食道筛查来修改FEES检查，以用于早期发现食道吞咽困难。一个潜在的，单中心,试点研究。在标准费用考试结束时，病人被要求吞下一个空胶囊。十五秒后,将内窥镜插入上食管。当在食道中看到胶囊时，定义了病理胶囊测试。在这种情况下,患者被建议接受胃镜检查，MBS,或者食道测压,将其与胶囊测试的结果进行比较。在109名患者中使用胶囊测试。55例患者（57.8％）进行了病理包膜检查。在48例患者（87.3%）中，观察到孤立或合并的食道吞咽困难。胶囊试验与胃肠病学试验相比的准确率为83.3%,灵敏度88.46%,特异性75%，PPV85%,和NPV80%。通过包括空胶囊吞咽测试和上食道检查来修改标准FEES检查可以为食道吞咽困难提供有用的筛查工具。
