Abstract：
OBJECTIVE: Abscopal effects have been reported predominantly in metastatic cancers, indicating a radiographic response in a lesion that has not been included in the radiotherapy target volume. The response is interpreted as a humoral immune response to radiotherapy-generated tumour-specific antigens. In this case study, we present the first histologically confirmed multifocal low-grade meningioma with spontaneous regression of all other lesions after conventionally fractionated stereotactic radiotherapy (RT).
METHODS: Two localisations, right frontal and right spheno-orbital, were resected at the time of the initial diagnosis in a 66-year-old woman. RT was performed 1 year later to a progressive occipital lesion at the cerebral falx.
RESULTS: Regular magnetic resonance imaging (MRI) showed slightly decreasing tumour volume in untreated lesions 1 year after RT and continued during further follow-up. Up to > 7 years after treatment, MRI demonstrated an almost complete response of all initial lesions. Two prior reports with meningioma were published in one patient with an atypical meningioma after conventionally fractionated RT and another patient with an intracranial meningiomatosis after radiosurgery.
CONCLUSIONS: This case study supports the concepts of treating only progressive or symptomatic meningioma lesions locally and careful regular MRI surveillance for further assessment. Potential active interventions to trigger an abscopal effect are currently not known. Further research of this beneficial effect for our patients should be supported.
METHODS: Two localisations, right frontal and right spheno-orbital, were resected at the time of the initial diagnosis in a 66-year-old woman. RT was performed 1 year later to a progressive occipital lesion at the cerebral falx.
RESULTS: Regular magnetic resonance imaging (MRI) showed slightly decreasing tumour volume in untreated lesions 1 year after RT and continued during further follow-up. Up to > 7 years after treatment, MRI demonstrated an almost complete response of all initial lesions. Two prior reports with meningioma were published in one patient with an atypical meningioma after conventionally fractionated RT and another patient with an intracranial meningiomatosis after radiosurgery.
CONCLUSIONS: This case study supports the concepts of treating only progressive or symptomatic meningioma lesions locally and careful regular MRI surveillance for further assessment. Potential active interventions to trigger an abscopal effect are currently not known. Further research of this beneficial effect for our patients should be supported.
摘要：
目的：据报道，Abscopal效应主要发生在转移性癌症中，指示尚未包括在放射治疗目标体积中的病变的放射照相响应。该反应被解释为对放射疗法产生的肿瘤特异性抗原的体液免疫反应。在这个案例研究中,我们介绍了第一个经组织学证实的多灶性低级别脑膜瘤,常规分割立体定向放疗(RT)后所有其他病灶自发消退.
方法：两种定位，右额叶和右蝶眶，在最初诊断时切除了一名66岁的女性。1年后对大脑falx的进行性枕骨病变进行了RT。
结果：常规磁共振成像（MRI）显示，放疗后1年未治疗病变的肿瘤体积略有减小，并在进一步随访期间持续。治疗后超过7年，MRI显示所有初始病变几乎完全响应。在常规分割的RT后，一名非典型脑膜瘤患者和另一名放射外科手术后颅内脑膜瘤患者中，发表了两份脑膜瘤的先前报告。
结论：本病例研究支持仅局部治疗进行性或有症状的脑膜瘤病变，并仔细定期进行MRI监测以进行进一步评估的概念。目前尚不清楚潜在的主动干预措施来触发abscopal效应。应该支持对我们患者的这种有益作用的进一步研究。
方法：两种定位，右额叶和右蝶眶，在最初诊断时切除了一名66岁的女性。1年后对大脑falx的进行性枕骨病变进行了RT。
结果：常规磁共振成像（MRI）显示，放疗后1年未治疗病变的肿瘤体积略有减小，并在进一步随访期间持续。治疗后超过7年，MRI显示所有初始病变几乎完全响应。在常规分割的RT后，一名非典型脑膜瘤患者和另一名放射外科手术后颅内脑膜瘤患者中，发表了两份脑膜瘤的先前报告。
结论：本病例研究支持仅局部治疗进行性或有症状的脑膜瘤病变，并仔细定期进行MRI监测以进行进一步评估的概念。目前尚不清楚潜在的主动干预措施来触发abscopal效应。应该支持对我们患者的这种有益作用的进一步研究。
