PDF(Pubmed)
Abstract：
Low-grade chronic inflammation is associated with many age-related conditions. Non-invasive methods to monitor low-grade chronic inflammation may improve the management of older people at risk of poorer outcomes. This longitudinal cohort study has determined baseline inflammation using neopterin volatility in monthly urine samples of 45 independent older adults (aged 65-75 years). Measurement of neopterin, an inflammatory metabolite, enabled stratification of individuals into risk categories based on how often in a 12-month period their neopterin level was raised. Hearing was measured (pure-tone audiometry) at baseline, 1 year and 3 years of the study. Results show that those in the highest risk category (neopterin raised greater than 50% of the time) saw greater deterioration, particularly in high-frequency, hearing. A one-way Welch\'s ANOVA showed a significant difference between the risk categories for change in high-frequency hearing (W (3, 19.6) = 9.164, p = 0.0005). Despite the study size and duration individuals in the highest risk category were more than twice as likely to have an additional age-related morbidity than those in the lowest risk category. We conclude that volatility of neopterin in urine may enable stratification of those at greatest risk of progression of hearing loss.
摘要：
低度慢性炎症与许多与年龄相关的疾病有关。监测低度慢性炎症的非侵入性方法可能会改善预后较差的老年人的管理。这项纵向队列研究使用新蝶呤波动性在45名独立老年人（65-75岁）的每月尿液样本中确定了基线炎症。新蝶呤的测量，一种炎症代谢物，能够根据12个月内新蝶呤水平升高的频率,将个体分为风险类别.在基线测量听力（纯音测听），1年和3年的研究。结果表明，那些处于最高风险类别（新蝶呤增加超过50％的时间）的人出现了更大的恶化，特别是在高频，听证会。单向Welch的方差分析显示，高频听力变化的风险类别之间存在显着差异（W（3，19.6）=9.164，p=0.0005）。尽管研究规模和持续时间最高风险类别的个体比最低风险类别的个体具有额外的年龄相关发病率的可能性是两倍多。我们得出的结论是，尿液中新蝶呤的波动性可能会对听力损失进展风险最大的人群进行分层。
