Abstract：
OBJECTIVE: Many cancer patients develop bone metastases, however the prognosis of overall survival differs. To provide an optimal treatment for these patients, especially towards the end of life, a reliable prediction of survival is needed. The goal of this study was to find new clinical factors in relation to overall survival.
METHODS: Prospectively 22 clinical factors were collected from 734 patients. The Kaplan-Meier and Cox regression models were used.
RESULTS: Most patients were diagnosed with lung cancer (29%), followed by prostate (19.8%) and breast cancer (14.7%). Median overall survival was 6.4months. Fourteen clinical factors showed significance in the univariate analyses. In the multivariate analyses 6 factors were found to be significant for the overall survival: Karnofsky performance status, primary tumor, gender, total organs affected, morphine use and systemic treatment options after radiotherapy.
CONCLUSIONS: Morphine use and systemic treatment options after radiotherapy, Karnofsky performance status, primary tumor, gender and total organs affected are strong prediction factors on overall survival after palliative radiotherapy in patients with bone metastasis. These factors are easily applicable in the clinic.
METHODS: Prospectively 22 clinical factors were collected from 734 patients. The Kaplan-Meier and Cox regression models were used.
RESULTS: Most patients were diagnosed with lung cancer (29%), followed by prostate (19.8%) and breast cancer (14.7%). Median overall survival was 6.4months. Fourteen clinical factors showed significance in the univariate analyses. In the multivariate analyses 6 factors were found to be significant for the overall survival: Karnofsky performance status, primary tumor, gender, total organs affected, morphine use and systemic treatment options after radiotherapy.
CONCLUSIONS: Morphine use and systemic treatment options after radiotherapy, Karnofsky performance status, primary tumor, gender and total organs affected are strong prediction factors on overall survival after palliative radiotherapy in patients with bone metastasis. These factors are easily applicable in the clinic.
摘要：
目标：许多癌症患者会发生骨转移，然而，总体生存率的预后有所不同。为这些患者提供最佳治疗，尤其是在生命的尽头，需要可靠的生存预测。这项研究的目的是寻找与总生存期相关的新临床因素。
方法：从734例患者中收集22个临床因素。使用Kaplan-Meier和Cox回归模型。
结果：大多数患者被诊断为肺癌（29％），其次是前列腺癌(19.8%)和乳腺癌(14.7%)。中位总生存期为6.4个月。14个临床因素在单变量分析中显示出显著性。在多变量分析中，发现6个因素对总生存期有重要意义：Karnofsky表现状态，原发性肿瘤,性别,受影响的全部器官，放疗后吗啡的使用和全身治疗选择。
结论：放疗后吗啡的使用和全身治疗选择，Karnofsky性能状态，原发性肿瘤,性别和受影响的总器官是骨转移患者姑息性放疗后总生存期的强预测因素。这些因素在临床上很容易适用。
方法：从734例患者中收集22个临床因素。使用Kaplan-Meier和Cox回归模型。
结果：大多数患者被诊断为肺癌（29％），其次是前列腺癌(19.8%)和乳腺癌(14.7%)。中位总生存期为6.4个月。14个临床因素在单变量分析中显示出显著性。在多变量分析中，发现6个因素对总生存期有重要意义：Karnofsky表现状态，原发性肿瘤,性别,受影响的全部器官，放疗后吗啡的使用和全身治疗选择。
结论：放疗后吗啡的使用和全身治疗选择，Karnofsky性能状态，原发性肿瘤,性别和受影响的总器官是骨转移患者姑息性放疗后总生存期的强预测因素。这些因素在临床上很容易适用。
