PDF(Pubmed)
Abstract：
OBJECTIVE: Examine sensory function of the upper airway in four groups of subjects recruited from the World Trade Centre General Responder Cohort (WTCGRC), with/without obstructive sleep apnoea (OSA), and with/without chronic rhinosinusitis (CRS).
METHODS: Upper airway sensory function was determined using 2-point discrimination (2-PD) and vibration threshold (VT) in 163 WTCGRC subjects with both OSA and CRS (cases), OSA or CRS alone and without OSA or CRS (controls). Presence of OSA was determined from clinical sleep studies or home sleep testing. Presence of CRS was determined by nasal symptom questionnaire. The relationship between the presence of OSA and CRS and upper airway sensory impairment was assessed using linear regression analysis with each of 2PD and VT sensory threshold values as the dependent variable; OSA, CRS and their interaction were the independent variables. Age, gender and body mass index were covariates in the statistical model. The primary analysis was comparison of OSA+CRS versus controls (no OSA and no CRS) evaluated by linear contrasts.
RESULTS: There were no differences in 2-PD or VT in those with OSA+CRS, OSA and CRS alone or controls. However, both 2-PD and VT were significantly higher in the WTCGRC controls compared with values seen in historical controls using the same methodology (median 2-PD 13.0; CI (11.0 to 13.5) vs 10.5; CI (8 to 11); VT: mean±SEM (9.3±0.6 vs 2.2±0.1)).
CONCLUSIONS: While no differences were found in upper airway sensation between cases of OSA and CRS versus controls in the WTGRC population, there was evidence of impaired upper airway sensation in the WTGRC overall.
METHODS: Upper airway sensory function was determined using 2-point discrimination (2-PD) and vibration threshold (VT) in 163 WTCGRC subjects with both OSA and CRS (cases), OSA or CRS alone and without OSA or CRS (controls). Presence of OSA was determined from clinical sleep studies or home sleep testing. Presence of CRS was determined by nasal symptom questionnaire. The relationship between the presence of OSA and CRS and upper airway sensory impairment was assessed using linear regression analysis with each of 2PD and VT sensory threshold values as the dependent variable; OSA, CRS and their interaction were the independent variables. Age, gender and body mass index were covariates in the statistical model. The primary analysis was comparison of OSA+CRS versus controls (no OSA and no CRS) evaluated by linear contrasts.
RESULTS: There were no differences in 2-PD or VT in those with OSA+CRS, OSA and CRS alone or controls. However, both 2-PD and VT were significantly higher in the WTCGRC controls compared with values seen in historical controls using the same methodology (median 2-PD 13.0; CI (11.0 to 13.5) vs 10.5; CI (8 to 11); VT: mean±SEM (9.3±0.6 vs 2.2±0.1)).
CONCLUSIONS: While no differences were found in upper airway sensation between cases of OSA and CRS versus controls in the WTGRC population, there was evidence of impaired upper airway sensation in the WTGRC overall.
摘要：
目的：检查从世界贸易中心通用响应队列（WTCGRC）招募的四组受试者的上气道感觉功能，有/无阻塞性睡眠呼吸暂停（OSA），有/无慢性鼻-鼻窦炎（CRS）。
方法：在163名患有OSA和CRS（病例）的WTCGRC受试者中，使用2点辨别（2-PD）和振动阈值（VT）确定上呼吸道感觉功能，OSA或CRS单独且无OSA或CRS(对照)。根据临床睡眠研究或家庭睡眠测试确定OSA的存在。通过鼻症状问卷确定CRS的存在。以2PD和VT感觉阈值为因变量，使用线性回归分析评估OSA和CRS的存在与上呼吸道感觉障碍之间的关系；OSA，CRS及其相互作用是自变量。年龄,性别和体重指数是统计模型中的协变量.主要分析是通过线性对比评估的OSA+CRS与对照(无OSA和无CRS)的比较。
结果：OSA+CRS患者的2-PD或VT无差异，OSA和CRS单独或对照。然而,与使用相同方法的历史对照相比,WTCGRC对照中的2-PD和VT均显著较高(中位数2-PD13.0;CI(11.0~13.5)vs10.5;CI(8~11);VT:平均值±SEM(9.3±0.6vs2.2±0.1)).
结论：虽然在WTGRC人群中，OSA和CRS病例与对照组之间的上呼吸道感觉没有差异，WTGRC整体上有上呼吸道感觉受损的证据.
方法：在163名患有OSA和CRS（病例）的WTCGRC受试者中，使用2点辨别（2-PD）和振动阈值（VT）确定上呼吸道感觉功能，OSA或CRS单独且无OSA或CRS(对照)。根据临床睡眠研究或家庭睡眠测试确定OSA的存在。通过鼻症状问卷确定CRS的存在。以2PD和VT感觉阈值为因变量，使用线性回归分析评估OSA和CRS的存在与上呼吸道感觉障碍之间的关系；OSA，CRS及其相互作用是自变量。年龄,性别和体重指数是统计模型中的协变量.主要分析是通过线性对比评估的OSA+CRS与对照(无OSA和无CRS)的比较。
结果：OSA+CRS患者的2-PD或VT无差异，OSA和CRS单独或对照。然而,与使用相同方法的历史对照相比,WTCGRC对照中的2-PD和VT均显著较高(中位数2-PD13.0;CI(11.0~13.5)vs10.5;CI(8~11);VT:平均值±SEM(9.3±0.6vs2.2±0.1)).
结论：虽然在WTGRC人群中，OSA和CRS病例与对照组之间的上呼吸道感觉没有差异，WTGRC整体上有上呼吸道感觉受损的证据.
