Abstract：
Circadian Locomotor Output Cycles Kaput (CLOCK) is one of the circadian clock genes and is considered to be a fundamental regulatory gene in the circadian rhythm, responsible for mediating several biological processes. Therefore, abnormal expression of CLOCK affects its role in the circadian clock and its more general function as a direct regulator of gene expression. This dysfunction can lead to severe pathological effects, including cancer. To better understand the role of CLOCK in cancer, we compiled this review to describe the biological function of CLOCK, and especially highlighted its function in cancer development, progression, tumor microenvironment, cancer cell metabolism, and drug resistance.
摘要：
昼夜节律输出周期Kaput（CLOCK）是昼夜节律基因之一，被认为是昼夜节律中的基本调节基因，负责调解几个生物过程。因此,CLOCK的异常表达影响其在生物钟中的作用及其作为基因表达直接调节因子的更一般功能。这种功能障碍会导致严重的病理影响，包括癌症.为了更好地理解CLOCK在癌症中的作用，我们整理了这篇综述来描述时钟的生物学功能，特别强调了它在癌症发展中的作用，programming,肿瘤微环境,癌细胞代谢，和抗药性。
