Abstract：
UNASSIGNED: Long-term psychological impacts are well--documented among childhood cancer survivors. To our knowledge, however, no research has been conducted to investigate obsessive--compulsive and related disorders (OCRD) among childhood -cancer survivors (CCS).
UNASSIGNED: Using a large electronic medical record database, relative risk were calculated to examine associations between demographic characteristics and childhood cancer type and OCRDs among childhood cancer survivors.
UNASSIGNED: Among 121 survivors of childhood cancer diagnosed with OCRD, 57% were female. The most common childhood cancer diagnoses were leukemia/lymphoma (41%) and central nervous system (CNS) malignancies (38%), and OCRD diagnoses most frequently observed were obsessive-compulsive disorder (OCD; 76%) and excoriation disorder (13%). Female sex (RR= 1.39, 95% confidence interval (CI) 1.17-1.61), White race (RR= 1.28, 95% CI 1.15-1.36) and history of CNS malignancies (RR= 1.36, 95% CI 1.18, 1.92) were associated with OCD.
UNASSIGNED: Numerous factors, including sex, race, and cancer type, were seen as contributors to risk variance for OCRDs, particularly OCD, among CCS, compared to CCS with no OCRD diagnosis. This provides an enhanced understanding of risk factors for OCRD development and may help improve early identification and care for at-risk survivors.
UNASSIGNED: Using a large electronic medical record database, relative risk were calculated to examine associations between demographic characteristics and childhood cancer type and OCRDs among childhood cancer survivors.
UNASSIGNED: Among 121 survivors of childhood cancer diagnosed with OCRD, 57% were female. The most common childhood cancer diagnoses were leukemia/lymphoma (41%) and central nervous system (CNS) malignancies (38%), and OCRD diagnoses most frequently observed were obsessive-compulsive disorder (OCD; 76%) and excoriation disorder (13%). Female sex (RR= 1.39, 95% confidence interval (CI) 1.17-1.61), White race (RR= 1.28, 95% CI 1.15-1.36) and history of CNS malignancies (RR= 1.36, 95% CI 1.18, 1.92) were associated with OCD.
UNASSIGNED: Numerous factors, including sex, race, and cancer type, were seen as contributors to risk variance for OCRDs, particularly OCD, among CCS, compared to CCS with no OCRD diagnosis. This provides an enhanced understanding of risk factors for OCRD development and may help improve early identification and care for at-risk survivors.
摘要：
■长期的心理影响在儿童癌症幸存者中有很好的记录。据我们所知,然而,尚未进行研究调查儿童癌症幸存者（CCS）中的强迫症及相关疾病（OCRD）。
■使用大型电子病历数据库，在儿童癌症幸存者中,计算相对危险度以检查人口统计学特征与儿童癌症类型和OCRDs之间的关联.
■在121名被诊断患有OCRD的儿童癌症幸存者中，57%是女性。最常见的儿童癌症诊断是白血病/淋巴瘤（41％）和中枢神经系统（CNS）恶性肿瘤（38％）。最常见的OCRD诊断是强迫症（OCD;76％）和排骨障碍（13％）。女性（RR=1.39，95%置信区间（CI）1.17-1.61），白种人(RR=1.28,95%CI1.15-1.36)和中枢神经系统恶性肿瘤病史(RR=1.36,95%CI1.18,1.92)与强迫症相关。
■众多因素，包括性,种族,和癌症类型，被认为是OCRD风险方差的贡献者，特别是强迫症，在CCS中,与没有OCRD诊断的CCS相比。这为OCRD发展的风险因素提供了更深入的理解，并可能有助于改善对风险幸存者的早期识别和护理。
■使用大型电子病历数据库，在儿童癌症幸存者中,计算相对危险度以检查人口统计学特征与儿童癌症类型和OCRDs之间的关联.
■在121名被诊断患有OCRD的儿童癌症幸存者中，57%是女性。最常见的儿童癌症诊断是白血病/淋巴瘤（41％）和中枢神经系统（CNS）恶性肿瘤（38％）。最常见的OCRD诊断是强迫症（OCD;76％）和排骨障碍（13％）。女性（RR=1.39，95%置信区间（CI）1.17-1.61），白种人(RR=1.28,95%CI1.15-1.36)和中枢神经系统恶性肿瘤病史(RR=1.36,95%CI1.18,1.92)与强迫症相关。
■众多因素，包括性,种族,和癌症类型，被认为是OCRD风险方差的贡献者，特别是强迫症，在CCS中,与没有OCRD诊断的CCS相比。这为OCRD发展的风险因素提供了更深入的理解，并可能有助于改善对风险幸存者的早期识别和护理。
