Abstract：
The aim of this multicenter study was to evaluate the effectiveness and safety of electrochemotherapy (ECT) for the treatment of mucosal tumors in the head and neck. A total of 71 patients with 84 nodules of different histologies in the oral cavity, pharynx and larynx treated by ECT were evaluated. The data were collected from the InspECT database from 10 participating centers throughout Europe. Primary and recurrent/secondary tumors of different histologies were treated. The overall response rate was 65 %, with a 33 % complete response rate with limited side effects. The response rates of the primary and secondary tumors were not different. However, smaller tumors responded better than tumors larger than 3 cm in diameter. Furthermore, the tumors that were treated with curative intent responded significantly better than those treated with palliative intent. This study demonstrated the feasibility, safety and effectiveness of ECT in a larger cohort of patients with mucosal lesions in the head and neck region. Based on the available data, ECT can be used for the treatment of recurrent and, in some cases, primary mucosal tumors located in the oral cavity, larynx, and pharynx. A better response was obtained in patients with smaller primary tumors treated with curative intent.
摘要：
这项多中心研究的目的是评估电化学疗法（ECT）治疗头颈部粘膜肿瘤的有效性和安全性。共有71例患者的84个不同组织学的口腔结节，对ECT治疗的咽和喉进行了评估。数据是从来自欧洲10个参与中心的InspECT数据库中收集的。治疗不同组织学的原发性和复发性/继发性肿瘤。总有效率为65%，33％的完全缓解率，副作用有限。原发性和继发性肿瘤的反应率没有差异。然而,较小的肿瘤比直径大于3厘米的肿瘤反应更好。此外，治愈性治疗的肿瘤的疗效明显优于姑息性治疗.本研究证明了其可行性,在较大的头颈部粘膜病变患者队列中，ECT的安全性和有效性。根据现有数据，ECT可用于治疗复发,在某些情况下,位于口腔的原发性粘膜肿瘤，喉部,和咽部。在治愈性治疗的较小原发性肿瘤患者中获得了更好的反应。
