Abstract：
The congenital condition gastroschisis is associated with delayed villous development and placental malperfusion, suggesting placental involvement. This study uses RNA sequencing to compare the placental transcriptome in pregnancies with and without gastroschisis. 180 coding genes were differentially expressed, mapping to multiple gene ontology pathways. Altered placental gene expression may represent fetal signalling to the placenta, and these changes could contribute to the pathogenesis of gastroschisis and associated morbidities, including fetal growth restriction.
摘要：
先天性腹裂与绒毛发育延迟和胎盘灌注不良有关，提示胎盘受累。这项研究使用RNA测序来比较有和没有腹裂的妊娠中的胎盘转录组。180个编码基因差异表达，映射到多个基因本体途径。胎盘基因表达的改变可能代表胎盘的胎儿信号，这些变化可能有助于胃裂的发病机制和相关的发病率，包括胎儿生长受限.
