Abstract：
BACKGROUND: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. VWD is characterized by an abnormal quantity or quality of von Willebrand Factor (VWF). Anemia is often found at presentation for a bleeding disorder evaluation due to chronic blood loss.
OBJECTIVE: We hypothesized that anemia is associated with elevations in both VWF and factor VIII (FVIII) over baseline. We also hypothesized that obesity would be associated with increased levels of VWF.
METHODS: We conducted a single-center review of the electronic health record for patients that had proximal von Willebrand profiles and Hb data.
RESULTS: We identified 4552 unique subjects with VWF studies and a CBC within 24 h. We found that decreasing hemoglobin inversely correlated with VWF antigen, VWF ristocetin cofactor activity, and FVIII activity. We also found that obesity and Black race were independently associated with increased VWF antigen, activity, and FVIII activity. Hb, race, and body mass index (BMI) continued to be determinants of VWF and FVIII levels in multivariable analysis.
CONCLUSIONS: Our study demonstrates that anemia, race, and BMI were found to be associated with elevation of VWF antigen, VWF activity, and FVIII levels. As many individuals with anemia present for evaluation for a bleeding disorder, these variables need to be considered.
CONCLUSIONS: - Anemia was found to be associated with elevation of VWF antigen, VWF activity and FVIII levels. - Testing von Willebrand factor at times of anemia may mask a diagnosis of von Willebrand Disease.
OBJECTIVE: We hypothesized that anemia is associated with elevations in both VWF and factor VIII (FVIII) over baseline. We also hypothesized that obesity would be associated with increased levels of VWF.
METHODS: We conducted a single-center review of the electronic health record for patients that had proximal von Willebrand profiles and Hb data.
RESULTS: We identified 4552 unique subjects with VWF studies and a CBC within 24 h. We found that decreasing hemoglobin inversely correlated with VWF antigen, VWF ristocetin cofactor activity, and FVIII activity. We also found that obesity and Black race were independently associated with increased VWF antigen, activity, and FVIII activity. Hb, race, and body mass index (BMI) continued to be determinants of VWF and FVIII levels in multivariable analysis.
CONCLUSIONS: Our study demonstrates that anemia, race, and BMI were found to be associated with elevation of VWF antigen, VWF activity, and FVIII levels. As many individuals with anemia present for evaluation for a bleeding disorder, these variables need to be considered.
CONCLUSIONS: - Anemia was found to be associated with elevation of VWF antigen, VWF activity and FVIII levels. - Testing von Willebrand factor at times of anemia may mask a diagnosis of von Willebrand Disease.
摘要：
背景：血管性血友病（VWD）是最常见的遗传性出血性疾病。VWD的特征是vonWillebrand因子（VWF）的数量或质量异常。由于慢性失血，通常在出血性疾病评估中发现贫血。
目的：我们假设贫血与VWF和因子VIII（FVIII）相对于基线的升高有关。我们还假设肥胖与VWF水平升高有关。
方法：我们对近端的vonWillebrand患者的电子健康记录和Hb数据进行了单中心审查。
结果：我们确定了4552名具有VWF研究和24小时内CBC的独特受试者。我们发现血红蛋白降低与VWF抗原呈负相关，VWF瑞斯托霉素辅因子活性，和FVIII活性。我们还发现，肥胖和黑人种族与增加的VWF抗原独立相关，活动,和FVIII活性。Hb,种族,在多变量分析中，体重指数（BMI）仍然是VWF和FVIII水平的决定因素。
结论：我们的研究表明贫血，种族,发现BMI与VWF抗原升高有关，VWF活动,和FVIII水平。由于许多贫血患者在场评估出血性疾病，这些变量需要考虑。
结论：-发现贫血与VWF抗原升高有关，VWF活性和FVIII水平。-在贫血时测试vonWillebrand因子可能会掩盖vonWillebrand病的诊断。
目的：我们假设贫血与VWF和因子VIII（FVIII）相对于基线的升高有关。我们还假设肥胖与VWF水平升高有关。
方法：我们对近端的vonWillebrand患者的电子健康记录和Hb数据进行了单中心审查。
结果：我们确定了4552名具有VWF研究和24小时内CBC的独特受试者。我们发现血红蛋白降低与VWF抗原呈负相关，VWF瑞斯托霉素辅因子活性，和FVIII活性。我们还发现，肥胖和黑人种族与增加的VWF抗原独立相关，活动,和FVIII活性。Hb,种族,在多变量分析中，体重指数（BMI）仍然是VWF和FVIII水平的决定因素。
结论：我们的研究表明贫血，种族,发现BMI与VWF抗原升高有关，VWF活动,和FVIII水平。由于许多贫血患者在场评估出血性疾病，这些变量需要考虑。
结论：-发现贫血与VWF抗原升高有关，VWF活性和FVIII水平。-在贫血时测试vonWillebrand因子可能会掩盖vonWillebrand病的诊断。
