Abstract：
BACKGROUND: The goals of neuroimaging in idiopathic intracranial hypertension (IIH) are the exclusion of mimickers and effective management of disease. In recent studies, several imaging markers have been identified as potential predictors of IIH.
OBJECTIVE: To investigate the predictive roles of novel radiological markers as the Meckel\'s cave area, alongside classical radiologic markers in identifying IIH such as the empty sella.
METHODS: The patients were classified according to cerebrospinal fluid (CSF) opening pressure as the IIH group and control group. The observational, case-control study included 22 patients with IIH and 22 controls. Groups were compared for presence of empty sella, Meckel\'s cave area, fat area of posterior neck, fat thickness of scalp, presence of transverse sinus stenosis, and ophthalmic markers, such as increase of optic nerve (ON) sheath diameter.
RESULTS: In the IHH group, higher occurrences of increased ON sheath diameter, ON tortuosity, flattening of the scleral surface, and transverse sinus stenosis were observed (P < 0.001, P < 0.001, P = 0.046, and P = 0.021, respectively). Meckel\'s cave area and fat area of posterior neck were similar in both groups (P = 0.444 and P = 0.794).
CONCLUSIONS: Ophthalmic markers and transverse sinus stenosis could be utilized as radiologic features supporting early and precise diagnosis of IIH. However, enlargement of Meckel\'s cave area and measurements of fatty area of posterior neck are not helpful for diagnosis of IIH.
OBJECTIVE: To investigate the predictive roles of novel radiological markers as the Meckel\'s cave area, alongside classical radiologic markers in identifying IIH such as the empty sella.
METHODS: The patients were classified according to cerebrospinal fluid (CSF) opening pressure as the IIH group and control group. The observational, case-control study included 22 patients with IIH and 22 controls. Groups were compared for presence of empty sella, Meckel\'s cave area, fat area of posterior neck, fat thickness of scalp, presence of transverse sinus stenosis, and ophthalmic markers, such as increase of optic nerve (ON) sheath diameter.
RESULTS: In the IHH group, higher occurrences of increased ON sheath diameter, ON tortuosity, flattening of the scleral surface, and transverse sinus stenosis were observed (P < 0.001, P < 0.001, P = 0.046, and P = 0.021, respectively). Meckel\'s cave area and fat area of posterior neck were similar in both groups (P = 0.444 and P = 0.794).
CONCLUSIONS: Ophthalmic markers and transverse sinus stenosis could be utilized as radiologic features supporting early and precise diagnosis of IIH. However, enlargement of Meckel\'s cave area and measurements of fatty area of posterior neck are not helpful for diagnosis of IIH.
摘要：
背景：特发性颅内高压（IIH）神经影像学的目标是排除模拟者和有效管理疾病。在最近的研究中,一些影像学标志物已被确定为IIH的潜在预测因子.
目的：为了研究新的放射标记物作为Meckel洞穴区域的预测作用，与识别IIH的经典放射学标记物一起，例如空蝶鞍。
方法：根据脑脊液（CSF）开放压力将患者分为IIH组和对照组。观察,病例对照研究包括22例IIH患者和22例对照.小组比较了空蝶鞍的存在，Meckel的洞穴区域,后颈脂肪区，头皮的脂肪厚度，横窦狭窄的存在，和眼科标记，如增加视神经(ON)鞘直径。
结果：在IHH组中，套管直径增加的发生率更高，弯曲时，巩膜表面变平，并观察到横窦狭窄（分别为P<0.001，P<0.001，P=0.046和P=0.021）。两组Meckel的洞穴面积和后颈脂肪面积相似(P=0.444和P=0.794)。
结论：眼科标志物和横窦狭窄可作为支持IIH早期和准确诊断的影像学特征。然而,扩大Meckel的洞穴面积和测量后颈部脂肪面积对诊断IIH没有帮助。
目的：为了研究新的放射标记物作为Meckel洞穴区域的预测作用，与识别IIH的经典放射学标记物一起，例如空蝶鞍。
方法：根据脑脊液（CSF）开放压力将患者分为IIH组和对照组。观察,病例对照研究包括22例IIH患者和22例对照.小组比较了空蝶鞍的存在，Meckel的洞穴区域,后颈脂肪区，头皮的脂肪厚度，横窦狭窄的存在，和眼科标记，如增加视神经(ON)鞘直径。
结果：在IHH组中，套管直径增加的发生率更高，弯曲时，巩膜表面变平，并观察到横窦狭窄（分别为P<0.001，P<0.001，P=0.046和P=0.021）。两组Meckel的洞穴面积和后颈脂肪面积相似(P=0.444和P=0.794)。
结论：眼科标志物和横窦狭窄可作为支持IIH早期和准确诊断的影像学特征。然而,扩大Meckel的洞穴面积和测量后颈部脂肪面积对诊断IIH没有帮助。
