Abstract：
OBJECTIVE: This article aims to illustrate the current state of investigations and management of liver metastases in patients with Neuroendocrine Neoplasms. Neuroendocrine tumours (NETs) are rising in incidence globally and have become the second most prevalent gastrointestinal malignancy in UK and USA. Frequently, patients have metastatic disease at time of presentation. The liver is the most common site of metastases for gastro-enteropancreatic NETs. Characterisation of liver metastases with imaging is important to ensure disease is not under-staged.
RESULTS: Magnetic resonance imaging and positron emission tomography are now becoming standard of care for imaging liver metastases. There is an increasing armamentarium of therapies available for management of NETs and loco-regional therapy for liver metastases. The data supporting surgical and loco-regional therapy is reviewed with focus on role of liver transplantation. It is important to use appropriate imaging and classification of NET liver metastases. It is key that decisions regarding approach to treatment is undertaken in a multidisciplinary team and that individualised approaches are considered for management of patients with metastatic NETs.
RESULTS: Magnetic resonance imaging and positron emission tomography are now becoming standard of care for imaging liver metastases. There is an increasing armamentarium of therapies available for management of NETs and loco-regional therapy for liver metastases. The data supporting surgical and loco-regional therapy is reviewed with focus on role of liver transplantation. It is important to use appropriate imaging and classification of NET liver metastases. It is key that decisions regarding approach to treatment is undertaken in a multidisciplinary team and that individualised approaches are considered for management of patients with metastatic NETs.
摘要：
目的：本文旨在说明神经内分泌肿瘤患者肝转移的研究和治疗现状。神经内分泌肿瘤（NETs）在全球范围内的发病率正在上升，并已成为英国和美国第二常见的胃肠道恶性肿瘤。经常,患者在就诊时具有转移性疾病。肝脏是胃肠胰腺NETs最常见的转移部位。通过成像表征肝转移对于确保疾病不低于分期是重要的。
结果：磁共振成像和正电子发射断层扫描现在已成为肝转移成像的标准治疗方法。越来越多的治疗方法可用于NETs的管理和肝转移的局部区域治疗。回顾了支持手术和局部区域治疗的数据，重点是肝移植的作用。NET肝转移瘤的恰当成像和分类是重要的。关键是在多学科团队中进行有关治疗方法的决策，并且考虑将个性化方法用于转移性NETs患者的管理。
结果：磁共振成像和正电子发射断层扫描现在已成为肝转移成像的标准治疗方法。越来越多的治疗方法可用于NETs的管理和肝转移的局部区域治疗。回顾了支持手术和局部区域治疗的数据，重点是肝移植的作用。NET肝转移瘤的恰当成像和分类是重要的。关键是在多学科团队中进行有关治疗方法的决策，并且考虑将个性化方法用于转移性NETs患者的管理。
