关键词: blood group antigens human erythrocyte antigen programmable calculator transfusion medicine

来  源:   DOI:10.1093/ajcp/aqae070

Abstract:
OBJECTIVE: This study aimed to establish a comprehensive human erythrocyte antigen (HEA) frequency data set for Koreans. It also sought to develop a mobile app that facilitates the calculation of the frequencies of specific antigen-negative red blood cell units and the average number of units required for antigen typing.
METHODS: Human erythrocyte antigen frequencies were compiled from large-scale blood donor data and 5 previous papers. Based on the collected data, we developed a mobile calculator app for HEA frequency and evaluated its usability.
RESULTS: Human erythrocyte antigen frequency data for 20 blood group systems, including the ABO, Rh, MNS, Duffy, Kidd, and Diego systems, were established. The app was designed to enable users to select the desired phenotype from a drop-down menu and display the calculated frequency at the bottom. The number of units required for antigen typing to find 1 compatible red blood cell unit was also displayed. Five users participated in app evaluation and rated the functionality and information categories highly. In quizzes prompting users to calculate frequencies using the app, all participants provided correct answers, confirming the app\'s user-friendly functionality.
CONCLUSIONS: This app, which encompasses comprehensive HEA frequency data, is expected to find multiple uses in transfusion medicine, including optimizing blood bank workflow and defining rare blood groups in Korea.
摘要:
目的:本研究旨在为韩国人建立全面的人类红细胞抗原(HEA)频率数据集。它还试图开发一种移动应用程序,以促进计算特定抗原阴性红细胞单位的频率和抗原分型所需的平均单位数。
方法:人类红细胞抗原频率是从大规模献血者数据和5篇以前的论文中汇编的。根据收集的数据,我们开发了HEA频率的移动计算器应用程序,并评估了其可用性。
结果:20个血型系统的人类红细胞抗原频率数据,包括ABO,Rh,MNS,Duffy,基德,和迭戈系统,已建立。该应用程序旨在使用户能够从下拉菜单中选择所需的表型,并在底部显示计算出的频率。还显示了抗原分型以找到1个相容的红细胞单位所需的单位数。五名用户参与了应用程序评估,并对功能和信息类别进行了高度评价。在提示用户使用应用程序计算频率的测验中,所有参与者都提供了正确的答案,确认应用程序的用户友好的功能。
结论:此应用程序,包括全面的HEA频率数据,有望在输血医学中找到多种用途,包括优化血库工作流程和定义韩国的稀有血型。
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