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Abstract：
Background: Hematological cancer patients are prone to the development of sarcopenia and impaired nutritional and functional status. SARC-CalF is a screening tool for the risk of sarcopenia that has shown good results in this population. This study aimed to identify the risk of sarcopenia by SARC-CalF and to verify its association with nutritional status and Hand Grip Strength (HGS) in patients with hematological cancer. Materials and Methods: Adult patients, of both sexes, with hematological cancer, and in outpatient care participated in the study. We measured the Hand Grip Strength of the Dominant Hand (HGSD) and the Adductor Pollicis Muscle Thickness of the Dominant Hand (APMTD). Moreover, we applied the Patient-Generated Subjective Global Assessment (PG-SGA) and SARC-CalF. Data were analyzed with SPSS® software, 22.0, with a significance level of 5.0%. Results: Fifty-one patients aged an average of 60.4 ± 15.1 years were evaluated. Of those, 58.8% were elderly, 51% female, and 80.4% declared themselves non-white. The predominant diagnosis was Mature B Lymphoid Cell Neoplasia (37.7%), and 60.8% of the patients had a diagnosis time of ≤ 3 years. PG-SGA revealed that 35.3% of the patients were malnourished; APMTD and HGSD revealed that 60.8% and 25.5% had reduced muscle strength, respectively. SARC-CalF exposed that 39.2% of the patients were at risk for sarcopenia. Significant associations were found between SARC-CalF and diagnosis time ≤ 3 years (p = 0.039), PG-SGA (p = 0.020), APMTD (p = 0.039) and HGSD (p = 0.002). After binary logistic regression adjusted for age and sex, the reduced HGSD remained associated with the risk of sarcopenia. Conclusion: SARC-CalF identified a risk of sarcopenia in 39.2% of patients. The reduced HGSD was associated with the risk of sarcopenia.
摘要：
背景：血液肿瘤患者容易发生肌肉减少症，营养和功能状态受损。SARC-CalF是一种针对少肌症风险的筛查工具，在该人群中显示出良好的结果。这项研究旨在通过SARC-CalF确定肌肉减少症的风险，并验证其与血液癌症患者的营养状况和握力（HGS）的关系。材料和方法：成年患者，两性，患有血液癌症，并在门诊护理中参与了这项研究。我们测量了优势手的握力（HGSD）和优势手的内收肌Policis肌肉厚度（APMTD）。此外，我们应用了患者主观整体评估（PG-SGA）和SARC-CalF。数据采用SPSS®软件进行分析,22.0，显著性水平为5.0%。结果:51例患者平均年龄60.4±15.1岁。其中,58.8%是老年人，51%女性,80.4%的人声称自己不是白人。主要诊断为成熟B淋巴样细胞瘤(37.7%),60.8%的患者诊断时间≤3年。PG-SGA显示35.3%的患者营养不良；APMTD和HGSD显示60.8%和25.5%的患者肌肉力量下降，分别。SARC-CalF揭示39.2%的患者存在肌肉减少症的风险。发现SARC-CalF与诊断时间≤3年之间存在显着关联（p=0.039），PG-SGA（p=0.020），APMTD(p=0.039)和HGSD(p=0.002)。在调整了年龄和性别的二元逻辑回归后，HGSD降低仍与少肌症风险相关.结论：SARC-CalF在39.2%的患者中发现了少肌症的风险。HGSD降低与少肌症的发病风险相关。
