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Abstract：
UNASSIGNED: The current clinical practice lacks sufficient objective indicators for evaluating thyroid-associated ophthalmopathy (TAO). This study aims to quantitatively assess TAO by evaluating levator palpebrae superioris (LPS) using Dixon-T2WI.
UNASSIGNED: The retrospective study included 231 eyes (119 patients) in the TAO group and 78 eyes (39 volunteers) in the normal group. Dixon-T2WI provided data on maximum thickness of LPS (LPS_T) and signal intensity ratio (LPS_SIR) between the muscle and ipsilateral brain white matter. TAO diagnosis and assessment of its activity and severity were quantitatively determined using LPS_T and LPS_SIR.
UNASSIGNED: In the TAO group, LPS_T and LPS_SIR were higher than those in the normal group (p < 2.2e-16). The upper lid retraction (ULR) ≥ 2 mm group exhibited higher LPS_T and LPS_SIR compared to the ULR < 2 mm and normal groups. Optimal diagnostic performance was achieved with an AUC of 0.91 for LPS_T (cutoff: 1.505 mm) and 0.81 for LPS_SIR (cutoff: 1.170). LPS_T (p = 2.8e-07) and LPS_SIR (p = 3.9e-12) in the active phase were higher than in the inactive phase. LPS_T and LPS_SIR showed differences among the mild, moderate-to-severe, and sight-threatening groups (p < 0.05). ROC showed an AUC of 0.70 for LPS_T (cutoff: 2.095 mm) in judging the active phase, and 0.78 for LPS_SIR (cutoff: 1.129). For judging the moderate-to-severe and above, AUC was 0.76 for LPS_T (cutoff: 2.095 mm) and 0.78 for LPS_SIR (cutoff: 1.197).
UNASSIGNED: The maximum thickness and SIR of LPS provide imaging indicators for assisting in the diagnosis and quantitative evaluation of TAO.
UNASSIGNED: The retrospective study included 231 eyes (119 patients) in the TAO group and 78 eyes (39 volunteers) in the normal group. Dixon-T2WI provided data on maximum thickness of LPS (LPS_T) and signal intensity ratio (LPS_SIR) between the muscle and ipsilateral brain white matter. TAO diagnosis and assessment of its activity and severity were quantitatively determined using LPS_T and LPS_SIR.
UNASSIGNED: In the TAO group, LPS_T and LPS_SIR were higher than those in the normal group (p < 2.2e-16). The upper lid retraction (ULR) ≥ 2 mm group exhibited higher LPS_T and LPS_SIR compared to the ULR < 2 mm and normal groups. Optimal diagnostic performance was achieved with an AUC of 0.91 for LPS_T (cutoff: 1.505 mm) and 0.81 for LPS_SIR (cutoff: 1.170). LPS_T (p = 2.8e-07) and LPS_SIR (p = 3.9e-12) in the active phase were higher than in the inactive phase. LPS_T and LPS_SIR showed differences among the mild, moderate-to-severe, and sight-threatening groups (p < 0.05). ROC showed an AUC of 0.70 for LPS_T (cutoff: 2.095 mm) in judging the active phase, and 0.78 for LPS_SIR (cutoff: 1.129). For judging the moderate-to-severe and above, AUC was 0.76 for LPS_T (cutoff: 2.095 mm) and 0.78 for LPS_SIR (cutoff: 1.197).
UNASSIGNED: The maximum thickness and SIR of LPS provide imaging indicators for assisting in the diagnosis and quantitative evaluation of TAO.
摘要：
■目前的临床实践缺乏足够的客观指标来评估甲状腺相关眼病（TAO）。本研究旨在通过使用Dixon-T2WI评估上睑提肌（LPS）来定量评估TAO。
■回顾性研究包括TAO组231只眼（119例患者）和正常组78只眼（39例志愿者）。Dixon-T2WI提供了肌肉和同侧脑白质之间的LPS最大厚度（LPS_T）和信号强度比（LPS_SIR）的数据。使用LPS_T和LPS_SIR定量确定TAO诊断和评估其活性和严重程度。
■在TAO组中，LPS_T和LPS_SIR高于正常组(p<2.2e-16)。与ULR<2mm和正常组相比，上眼睑回缩（ULR）≥2mm组表现出更高的LPS_T和LPS_SIR。对于LPS_T(截止值:1.505mm)和LPS_SIR(截止值:1.170),AUC为0.81,实现了最佳诊断性能。活动阶段的LPS_T(p=2.8e-07)和LPS_SIR(p=3.9e-12)高于非活动阶段。LPS_T和LPS_SIR在轻度，中度至重度,和视力威胁组(p<0.05)。在判断活跃期时，ROC显示LPS_T的AUC为0.70（截止：2.095mm），LPS_SIR为0.78(截止值:1.129)。为了判断中度至重度及以上，LPS_T的AUC为0.76(截止值:2.095mm),LPS_SIR的AUC为0.78(截止值:1.197)。
■LPS的最大厚度和SIR为辅助TAO的诊断和定量评估提供了成像指标。
■回顾性研究包括TAO组231只眼（119例患者）和正常组78只眼（39例志愿者）。Dixon-T2WI提供了肌肉和同侧脑白质之间的LPS最大厚度（LPS_T）和信号强度比（LPS_SIR）的数据。使用LPS_T和LPS_SIR定量确定TAO诊断和评估其活性和严重程度。
■在TAO组中，LPS_T和LPS_SIR高于正常组(p<2.2e-16)。与ULR<2mm和正常组相比，上眼睑回缩（ULR）≥2mm组表现出更高的LPS_T和LPS_SIR。对于LPS_T(截止值:1.505mm)和LPS_SIR(截止值:1.170),AUC为0.81,实现了最佳诊断性能。活动阶段的LPS_T(p=2.8e-07)和LPS_SIR(p=3.9e-12)高于非活动阶段。LPS_T和LPS_SIR在轻度，中度至重度,和视力威胁组(p<0.05)。在判断活跃期时，ROC显示LPS_T的AUC为0.70（截止：2.095mm），LPS_SIR为0.78(截止值:1.129)。为了判断中度至重度及以上，LPS_T的AUC为0.76(截止值:2.095mm),LPS_SIR的AUC为0.78(截止值:1.197)。
■LPS的最大厚度和SIR为辅助TAO的诊断和定量评估提供了成像指标。
