PDF(Pubmed)
Abstract：
UNASSIGNED: Serotonin syndrome is characterized by mental status changes, autonomic hyperactivity, and neuromuscular abnormalities. This syndrome results from various medications that engender serotonergic overactivity. Atomoxetine is a norepinephrine reuptake inhibitor used for the treatment of attention-deficit hyperactivity disorder (ADHD). Two case reports have described serotonin syndrome induced by the combination of atomoxetine with venlafaxine or methylphenidate, but no report describes this syndrome induced by atomoxetine alone. This report describes serotonin syndrome induced solely by an overdose of atomoxetine in a patient with ADHD.
UNASSIGNED: The patient in this case was a 21-year-old man who had been treated with atomoxetine for ADHD. He was transported to our hospital 1 h after intentional ingestion of 1200 mg of atomoxetine in a suicide attempt. On admission, he showed profuse diaphoresis, marked agitation, somnolence, slight fever, tachycardia, prolonged QT interval, myoclonus, tremor, and hyperreflexia. He was diagnosed as having serotonin syndrome and was treated with administration of activated charcoal and massive infusion. Three days later, his serotonin syndrome symptoms had disappeared completely.
UNASSIGNED: Findings in this case suggest that atomoxetine alone can cause serotonin syndrome presumably via its effects of serotonin reuptake inhibition. Clinicians should consider this syndrome induced by atomoxetine overdose.
UNASSIGNED: The patient in this case was a 21-year-old man who had been treated with atomoxetine for ADHD. He was transported to our hospital 1 h after intentional ingestion of 1200 mg of atomoxetine in a suicide attempt. On admission, he showed profuse diaphoresis, marked agitation, somnolence, slight fever, tachycardia, prolonged QT interval, myoclonus, tremor, and hyperreflexia. He was diagnosed as having serotonin syndrome and was treated with administration of activated charcoal and massive infusion. Three days later, his serotonin syndrome symptoms had disappeared completely.
UNASSIGNED: Findings in this case suggest that atomoxetine alone can cause serotonin syndrome presumably via its effects of serotonin reuptake inhibition. Clinicians should consider this syndrome induced by atomoxetine overdose.
摘要：
■5-羟色胺综合征的特点是精神状态的变化，自主神经活动过度,和神经肌肉异常。这种综合征是由各种引起血清素能过度活动的药物引起的。阿托莫西汀是一种去甲肾上腺素再摄取抑制剂，用于治疗注意力缺陷多动障碍（ADHD）。两个病例报告描述了托莫西汀与文拉法辛或哌醋甲酯联合使用引起的5-羟色胺综合征，但是没有报告描述这种由托莫西汀单独引起的综合征。该报告描述了仅由过量使用托莫西汀引起的多动症患者的5-羟色胺综合征。
该病例的患者是一名21岁的男性，他曾接受托莫西汀治疗多动症。在自杀未遂中故意摄入1200mg托莫西汀后1小时，他被送往我们医院。一入场,他表现出大量的出汗，明显的激动，嗜睡,轻微发烧,心动过速,QT间期延长，肌阵鸣,震颤,和反射亢进.他被诊断为患有5-羟色胺综合征，并接受了活性炭和大量输注的治疗。三天后,他的5-羟色胺综合征症状已经完全消失.
■在这种情况下的研究结果表明，托莫西汀单独可以通过其抑制5-羟色胺再摄取的作用引起5-羟色胺综合征。临床医生应考虑这种由托莫西汀过量引起的综合征。
该病例的患者是一名21岁的男性，他曾接受托莫西汀治疗多动症。在自杀未遂中故意摄入1200mg托莫西汀后1小时，他被送往我们医院。一入场,他表现出大量的出汗，明显的激动，嗜睡,轻微发烧,心动过速,QT间期延长，肌阵鸣,震颤,和反射亢进.他被诊断为患有5-羟色胺综合征，并接受了活性炭和大量输注的治疗。三天后,他的5-羟色胺综合征症状已经完全消失.
■在这种情况下的研究结果表明，托莫西汀单独可以通过其抑制5-羟色胺再摄取的作用引起5-羟色胺综合征。临床医生应考虑这种由托莫西汀过量引起的综合征。
