METHODS: Seventy-one (34 female, non-pregnant, non-lactating) adults with newly diagnosed T2DM were recruited in this short-duration pilot study after obtaining written informed consent. Patients regularly taking any drug were excluded, as were patients with chronic comorbidities. Treatment was initiated with metformin 500 mg OD. Lifestyle changes were recommended according to the age and physical condition of the patients. Anthropometric parameters (age, weight, height, BMI, waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR)), blood pressure, glycemic status (fasting and 2 h PP glucose and HbA1c), and lipid profile of the subjects were recorded before initiating and six months after initiating metformin monotherapy with lifestyle changes.
RESULTS: Small but statistically significant improvements were observed in the WHR,WHtR, blood pressure, blood glucose, and glycated hemoglobin. Although improvement was also observed in weight and lipid profile, these changes were not statistically significant.
CONCLUSIONS: This study shows that metformin monotherapy with lifestyle changes is suitable for patients of Indian origin and results in improvement in the WHR, WHtR, blood pressure, plasma glucose, and glycated hemoglobin.
方法:71(34名女性,没有怀孕,在获得书面知情同意书后,在这项短期试点研究中招募了非哺乳期)新诊断的2型糖尿病成人.定期服用任何药物的患者被排除在外,慢性合并症患者也是如此。用二甲双胍500mgOD开始治疗。根据患者的年龄和身体状况,建议改变生活方式。人体测量参数(年龄,体重,高度,BMI,腰臀比(WHR),和腰围高度比(WHtR)),血压,血糖状态(空腹和2小时PP葡萄糖和HbA1c),在开始二甲双胍单药治疗前和开始后6个月,随着生活方式的改变,记录受试者的血脂状况.
结果:在WHR中观察到微小但具有统计学意义的改善,WHtR,血压,血糖,和糖化血红蛋白.虽然在体重和血脂方面也观察到改善,这些变化没有统计学意义.
结论:这项研究表明,改变生活方式的二甲双胍单药治疗适用于印度裔患者,并可改善WHR,WHtR,血压,血浆葡萄糖,和糖化血红蛋白.