PDF(Pubmed)
Abstract：
UNASSIGNED: This study aimed to clarify the abnormalities in dopamine transporter (DAT) availability in drug-naive adult patients with attention-deficit/hyperactivity disorder (ADHD) and the relationship between ADHD symptoms and abnormalities in DAT availability.
UNASSIGNED: Single-photon emission tomography (SPECT) was performed using iodine-123-β-carbomethoxy-3β-(4-iodophenyltropane) (I-123 β CIT) as a tracer to measure in vivo DAT availability in 20 drug-naive patients with ADHD [mean age ± standard deviation (SD)]: 25 ± 3.44 years; male:female = 11:9] and 20 age- and sex-matched healthy controls (HCs) (mean age ± SD: 23.9 ± 2.27 years). Comparisons of DAT availability between HCs and adult patients with ADHD and the association between symptom severity and DAT availability within the ADHD group were analyzed using Statistical Parametric Mapping 12.
UNASSIGNED: Drug-naive adults with ADHD showed significantly reduced DAT availability in the bilateral nucleus accumbens compared with HCs. Correlation analyses revealed a negative correlation between the severity of inattentive symptoms in adult patients with ADHD and DAT availability in the bilateral heads of the caudate nucleus, indicating the association between severe inattentive symptoms and lower DAT availability in the caudate nucleus.
UNASSIGNED: In drug-naive adult patients with ADHD, DAT availability was reduced in the nucleus accumbens, an important part of the reward system. This finding indicates the importance of the DAT in the reward system in the pathogenesis of ADHD. Inattentiveness was associated with DAT availability in the caudate nucleus, suggesting involvement of the cortico-striato-thalamo-cortical circuit.
UNASSIGNED: Single-photon emission tomography (SPECT) was performed using iodine-123-β-carbomethoxy-3β-(4-iodophenyltropane) (I-123 β CIT) as a tracer to measure in vivo DAT availability in 20 drug-naive patients with ADHD [mean age ± standard deviation (SD)]: 25 ± 3.44 years; male:female = 11:9] and 20 age- and sex-matched healthy controls (HCs) (mean age ± SD: 23.9 ± 2.27 years). Comparisons of DAT availability between HCs and adult patients with ADHD and the association between symptom severity and DAT availability within the ADHD group were analyzed using Statistical Parametric Mapping 12.
UNASSIGNED: Drug-naive adults with ADHD showed significantly reduced DAT availability in the bilateral nucleus accumbens compared with HCs. Correlation analyses revealed a negative correlation between the severity of inattentive symptoms in adult patients with ADHD and DAT availability in the bilateral heads of the caudate nucleus, indicating the association between severe inattentive symptoms and lower DAT availability in the caudate nucleus.
UNASSIGNED: In drug-naive adult patients with ADHD, DAT availability was reduced in the nucleus accumbens, an important part of the reward system. This finding indicates the importance of the DAT in the reward system in the pathogenesis of ADHD. Inattentiveness was associated with DAT availability in the caudate nucleus, suggesting involvement of the cortico-striato-thalamo-cortical circuit.
摘要：
■本研究旨在阐明注意力缺陷/多动障碍（ADHD）未服用药物的成年患者的多巴胺转运体（DAT）可用性异常以及ADHD症状与DAT可用性异常之间的关系。
■使用碘-123-β-甲氧甲氧基-3β-（4-碘苯基氨）（I-123βCIT）作为示踪剂进行了单光子发射断层扫描（SPECT），以测量20例未经治疗的ADHD患者的体内DAT可用性[平均年龄±标准差（SD）]：25±3.44岁；男性：11岁：平均性别-20使用统计参数映射12分析HCs与ADHD成年患者之间的DAT可用性以及ADHD组中症状严重程度与DAT可用性之间的关联。
■与HCs相比，未接受药物治疗的成人ADHD患者在双侧伏隔核中的DAT可用性显着降低。相关分析显示，成年ADHD患者注意力不集中症状的严重程度与尾状核双侧头部的DAT可用性呈负相关，表明严重的注意力不集中症状与尾状核中DAT可用性降低之间存在关联。
■在未服用药物的成年ADHD患者中，伏隔核的DAT可用性降低，奖励制度的重要组成部分。这一发现表明了奖励系统中DAT在ADHD发病机理中的重要性。注意力不集中与尾状核的DAT可用性有关，提示皮质-纹状体-丘脑-皮质回路受累。
■使用碘-123-β-甲氧甲氧基-3β-（4-碘苯基氨）（I-123βCIT）作为示踪剂进行了单光子发射断层扫描（SPECT），以测量20例未经治疗的ADHD患者的体内DAT可用性[平均年龄±标准差（SD）]：25±3.44岁；男性：11岁：平均性别-20使用统计参数映射12分析HCs与ADHD成年患者之间的DAT可用性以及ADHD组中症状严重程度与DAT可用性之间的关联。
■与HCs相比，未接受药物治疗的成人ADHD患者在双侧伏隔核中的DAT可用性显着降低。相关分析显示，成年ADHD患者注意力不集中症状的严重程度与尾状核双侧头部的DAT可用性呈负相关，表明严重的注意力不集中症状与尾状核中DAT可用性降低之间存在关联。
■在未服用药物的成年ADHD患者中，伏隔核的DAT可用性降低，奖励制度的重要组成部分。这一发现表明了奖励系统中DAT在ADHD发病机理中的重要性。注意力不集中与尾状核的DAT可用性有关，提示皮质-纹状体-丘脑-皮质回路受累。
