PDF(Pubmed)
Abstract：
Long COVID, characterized by persistent symptoms following a SARS-CoV-2 infection, presents a significant public health challenge with wide-ranging implications. This comprehensive review explores the epidemiology, clinical manifestations, pathogenesis, risk factors, diagnosis, patient impact, management strategies, and long-term prognosis of COVID. Despite a varied symptomatology that spans multiple organ systems, including respiratory, neurological, and cardiovascular systems, this condition is primarily associated with chronic inflammation and potential viral persistence. Prevalence varies, influenced by the initial infection severity, demographic factors, and pre-existing conditions. The review emphasizes the necessity for healthcare systems to adapt to the needs of long-COVID patients by developing standardized diagnostic criteria and personalized, multidisciplinary treatment approaches. Current research gaps and future directions are identified, highlighting the urgent need for further studies on pathophysiological mechanisms and effective therapeutic interventions. This review aims to inform healthcare providers, researchers, and policymakers, enhancing patient care and guiding ongoing and future research initiatives. The continuing global focus and collaborative efforts offer hope for improved outcomes for those affected by long COVID, marking an essential step towards addressing this emergent condition comprehensively.
摘要：
长COVID,以SARS-CoV-2感染后持续症状为特征，提出了具有广泛影响的重大公共卫生挑战。这篇全面的综述探讨了流行病学，临床表现，发病机制，危险因素，诊断,患者影响,管理策略，和COVID的长期预后。尽管跨越多个器官系统的各种症状，包括呼吸,神经学,和心血管系统，这种情况主要与慢性炎症和潜在的病毒持久性有关.患病率各不相同，受初始感染严重程度的影响，人口因素，和预先存在的条件。该评价强调，医疗保健系统必须通过制定标准化诊断标准和个性化诊断来适应长期COVID患者的需求，多学科治疗方法。确定了当前的研究差距和未来的方向，强调迫切需要进一步研究病理生理机制和有效的治疗干预措施。这篇评论旨在告知医疗保健提供者，研究人员,和政策制定者，加强患者护理，指导正在进行和未来的研究计划。持续的全球关注和合作努力为那些受长期COVID影响的人带来了改善结果的希望，标志着全面解决这一紧急情况的重要一步。
