Abstract：
To compare in-vitro fertilization (IVF) outcomes in polycystic ovary syndrome (PCOS) patients treated with follicle stimulating hormone (FSH) alone or FSH and luteinizing hormone (LH), under freeze-all gonadotropin-releasing hormone (GnRH) antagonist protocols.
This retrospective study at a university center included PCOS patients, who underwent freeze-all GnRH antagonist IVF cycles between January 2013 and December 2019. They were divided into FSH-only and FSH + LH groups, focusing on pregnancy and live birth rates.
The study included 82 patients: 43 received FSH + LH and 39 FSH only. Baseline characteristics were similar, except for higher thyroid stimulating hormone levels in the FSH-only group. The FSH + LH group required a lower mean ± standard deviation total dose of FSH (1271.5±376.7 vs. 1407.2±645.3 IU, p=0.02), had a shorter mean cycle length (7.3±3.4 vs. 8.3±1.6 days, p=0.004), and had a higher mean number of follicles stimulated (36.9±15.9 vs. 35.9±9.7, p=0.008) compared to the FSH-only group. No significant differences in pregnancy and live birth rates were noted at first transfer, but the cumulative live birth rate was significantly higher in the FSH-only group [30 of 39 (76.9%) vs. 24 of 43 (55.8%), p=0.044].
LH supplementation in PCOS patients undergoing GnRH antagonist IVF protocols may impair cumulative live birth rates, despite lowering FSH requirement and reducing IVF cycle length. These results highlight the complex role of LH in IVF outcomes for PCOS patients, suggesting a need for further large studies to fully understand the impact of LH in such treatments.
This retrospective study at a university center included PCOS patients, who underwent freeze-all GnRH antagonist IVF cycles between January 2013 and December 2019. They were divided into FSH-only and FSH + LH groups, focusing on pregnancy and live birth rates.
The study included 82 patients: 43 received FSH + LH and 39 FSH only. Baseline characteristics were similar, except for higher thyroid stimulating hormone levels in the FSH-only group. The FSH + LH group required a lower mean ± standard deviation total dose of FSH (1271.5±376.7 vs. 1407.2±645.3 IU, p=0.02), had a shorter mean cycle length (7.3±3.4 vs. 8.3±1.6 days, p=0.004), and had a higher mean number of follicles stimulated (36.9±15.9 vs. 35.9±9.7, p=0.008) compared to the FSH-only group. No significant differences in pregnancy and live birth rates were noted at first transfer, but the cumulative live birth rate was significantly higher in the FSH-only group [30 of 39 (76.9%) vs. 24 of 43 (55.8%), p=0.044].
LH supplementation in PCOS patients undergoing GnRH antagonist IVF protocols may impair cumulative live birth rates, despite lowering FSH requirement and reducing IVF cycle length. These results highlight the complex role of LH in IVF outcomes for PCOS patients, suggesting a need for further large studies to fully understand the impact of LH in such treatments.
摘要：
比较单用卵泡刺激素(FSH)或FSH和黄体生成素(LH)治疗的多囊卵巢综合征(PCOS)患者的体外受精(IVF)结局,在冷冻全促性腺激素释放激素（GnRH）拮抗剂方案下。
这项在大学中心进行的回顾性研究包括PCOS患者，他们在2013年1月至2019年12月期间接受了冻结所有GnRH拮抗剂IVF周期。他们被分为FSH-only和FSH+LH组，重点关注怀孕和活产率。
该研究包括82例患者：43例患者仅接受FSH+LH，39例患者仅接受FSH。基线特征相似，除了仅FSH组促甲状腺激素水平较高。FSH+LH组需要较低的平均±标准偏差总剂量的FSH（1271.5±376.7vs.1407.2±645.3IU,p=0.02),平均周期长度较短(7.3±3.4与8.3±1.6天，p=0.004),并且刺激的卵泡平均数量更高（36.9±15.9vs.35.9±9.7，p=0.008）与仅FSH组相比。首次转移时，妊娠和活产率没有显着差异，但是仅FSH组的累积活产率明显更高[39人中有30人（76.9％）与43人中的24人（55.8%），p=0.044]。
接受GnRH拮抗剂IVF方案的PCOS患者补充LH可能会损害累积活产率，尽管降低FSH要求和减少IVF周期长度。这些结果强调了LH在PCOS患者IVF结局中的复杂作用。这表明需要进一步的大型研究来充分了解LH在此类治疗中的影响。
这项在大学中心进行的回顾性研究包括PCOS患者，他们在2013年1月至2019年12月期间接受了冻结所有GnRH拮抗剂IVF周期。他们被分为FSH-only和FSH+LH组，重点关注怀孕和活产率。
该研究包括82例患者：43例患者仅接受FSH+LH，39例患者仅接受FSH。基线特征相似，除了仅FSH组促甲状腺激素水平较高。FSH+LH组需要较低的平均±标准偏差总剂量的FSH（1271.5±376.7vs.1407.2±645.3IU,p=0.02),平均周期长度较短(7.3±3.4与8.3±1.6天，p=0.004),并且刺激的卵泡平均数量更高（36.9±15.9vs.35.9±9.7，p=0.008）与仅FSH组相比。首次转移时，妊娠和活产率没有显着差异，但是仅FSH组的累积活产率明显更高[39人中有30人（76.9％）与43人中的24人（55.8%），p=0.044]。
接受GnRH拮抗剂IVF方案的PCOS患者补充LH可能会损害累积活产率，尽管降低FSH要求和减少IVF周期长度。这些结果强调了LH在PCOS患者IVF结局中的复杂作用。这表明需要进一步的大型研究来充分了解LH在此类治疗中的影响。
