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Abstract：
BACKGROUND: Anaplastic thyroid carcinoma(ATC) is a rare pathological type of thyroid malignancy. Primary squamous cell carcinoma of thyroid(PSCCT) is now considered as a subtype of ATC, hereinafter referred to as ATC-SCC subtype. ATC-SCC subtype combined with follicular thyroid carcinoma is exceedingly rare, with fewer cases reported. The ATC-SCC subtype is a highly invasive tumor with a poor prognosis for patients after metastasis occurs, and current treatment of this type of tumor is tricky.
METHODS: A 68-year-old female patient presented with a gradually growing swelling of right cervical region. Comprehensive auxiliary examinations and postoperative pathology confirmed the diagnosis of ATC-SCC subtype with follicular thyroid carcinoma, and the metastasis squamous cell carcinoma of the right cervical lymph nodes originates from ATC-SCC subtype. The patient received chemoradiotherapy postoperative. However, the residual cervical lymph nodes metastasis with squamous cell carcinoma still infiltrated surrounding structures in the neck extensively after palliative resection. The patient died 7 months after surgery.
CONCLUSIONS: Our case highlights that cervical lymph node metastasis may be a significant factor in the poor prognosis of ATC-SCC subtype. This malignancy should be detected and treated early.
METHODS: A 68-year-old female patient presented with a gradually growing swelling of right cervical region. Comprehensive auxiliary examinations and postoperative pathology confirmed the diagnosis of ATC-SCC subtype with follicular thyroid carcinoma, and the metastasis squamous cell carcinoma of the right cervical lymph nodes originates from ATC-SCC subtype. The patient received chemoradiotherapy postoperative. However, the residual cervical lymph nodes metastasis with squamous cell carcinoma still infiltrated surrounding structures in the neck extensively after palliative resection. The patient died 7 months after surgery.
CONCLUSIONS: Our case highlights that cervical lymph node metastasis may be a significant factor in the poor prognosis of ATC-SCC subtype. This malignancy should be detected and treated early.
摘要：
背景：间变性甲状腺癌（ATC）是甲状腺恶性肿瘤的一种罕见病理类型。原发性甲状腺鳞状细胞癌（PSCCT）现在被认为是ATC的一种亚型，以下简称ATC-SCC亚型。ATC-SCC亚型合并滤泡性甲状腺癌极为罕见，报告的病例较少。ATC-SCC亚型是一种高侵袭性肿瘤，转移后患者预后差，目前这种类型的肿瘤的治疗是棘手的。
方法：一名68岁女性患者表现为右宫颈区域逐渐肿胀。综合辅助检查和术后病理证实ATC-SCC亚型诊断为甲状腺滤泡状癌，右颈淋巴结转移鳞状细胞癌起源于ATC-SCC亚型。患者术后接受放化疗。然而,姑息性切除术后，残留的颈淋巴结转移伴鳞状细胞癌仍广泛浸润颈部周围结构。患者术后7个月死亡。
结论：我们的病例强调颈淋巴结转移可能是ATC-SCC亚型预后不良的重要因素。这种恶性肿瘤应及早发现和治疗。
方法：一名68岁女性患者表现为右宫颈区域逐渐肿胀。综合辅助检查和术后病理证实ATC-SCC亚型诊断为甲状腺滤泡状癌，右颈淋巴结转移鳞状细胞癌起源于ATC-SCC亚型。患者术后接受放化疗。然而,姑息性切除术后，残留的颈淋巴结转移伴鳞状细胞癌仍广泛浸润颈部周围结构。患者术后7个月死亡。
结论：我们的病例强调颈淋巴结转移可能是ATC-SCC亚型预后不良的重要因素。这种恶性肿瘤应及早发现和治疗。
