PDF(Pubmed)
Abstract：
BACKGROUND: Previous studies have shown a correlation between depression and obesity, as well as between depression and the Atherogenic Index of Plasma (AIP). However, there is limited research on the association between visceral obesity and depression, as well as the potential mediating role of AIP in this relationship.
METHODS: This study included 13,123 participants from the 2005-2018 National Health and Nutrition Examination Survey. Visceral obesity was measured with the Body Roundness Index (BRI), while depression was evaluated with the Patient Health Questionnaire-9. The AIP served as a marker for lipid disorders. To investigate the association between the BRI and depression, multivariate logistic regressions, restricted cubic spline models, subgroup analyses, and interaction tests were used. Additionally, a mediation analysis was conducted to explore the role of AIP in mediating the effect of BRI on depression.
RESULTS: There was a positive linear correlation between the BRI and depression. After controlling for all covariates, individuals in the highest BRI (Q4) group had an OR of 1.42 for depression (95% CI: 1.12-1.82) in comparison with individuals in the lowest BRI (Q1) group. Moreover, the AIP partially mediated the association between the BRI and depression, accounting for approximately 8.64% (95% CI: 2.04-16.00%) of the total effect.
CONCLUSIONS: The BRI was positively associated with depression, with the AIP playing a mediating role. This study provides a novel perspective on the mechanism that connects visceral obesity to depression. Managing visceral fat and monitoring AIP levels may contribute to alleviating depression.
METHODS: This study included 13,123 participants from the 2005-2018 National Health and Nutrition Examination Survey. Visceral obesity was measured with the Body Roundness Index (BRI), while depression was evaluated with the Patient Health Questionnaire-9. The AIP served as a marker for lipid disorders. To investigate the association between the BRI and depression, multivariate logistic regressions, restricted cubic spline models, subgroup analyses, and interaction tests were used. Additionally, a mediation analysis was conducted to explore the role of AIP in mediating the effect of BRI on depression.
RESULTS: There was a positive linear correlation between the BRI and depression. After controlling for all covariates, individuals in the highest BRI (Q4) group had an OR of 1.42 for depression (95% CI: 1.12-1.82) in comparison with individuals in the lowest BRI (Q1) group. Moreover, the AIP partially mediated the association between the BRI and depression, accounting for approximately 8.64% (95% CI: 2.04-16.00%) of the total effect.
CONCLUSIONS: The BRI was positively associated with depression, with the AIP playing a mediating role. This study provides a novel perspective on the mechanism that connects visceral obesity to depression. Managing visceral fat and monitoring AIP levels may contribute to alleviating depression.
摘要：
背景：以前的研究表明抑郁症和肥胖之间存在相关性，以及抑郁症和血浆动脉粥样硬化指数（AIP）之间。然而,关于内脏肥胖和抑郁之间关系的研究有限，以及AIP在这种关系中的潜在中介作用。
方法：这项研究包括2005-2018年全国健康和营养调查的13,123名参与者。内脏肥胖用身体圆度指数(BRI)测量，而抑郁症用患者健康问卷-9进行评估。AIP用作脂质紊乱的标志物。为了调查BRI与抑郁症之间的关系，多元逻辑回归，受限制的三次样条模型，亚组分析，并使用交互测试。此外,本研究进行了中介分析,以探讨AIP在BRI对抑郁的中介效应中的作用.
结果：BRI与抑郁症呈正线性相关。在控制所有协变量后，与BRI最低(Q1)组相比,BRI最高(Q4)组的抑郁症OR为1.42(95%CI:1.12~1.82).此外，AIP部分介导了BRI与抑郁症之间的关联，约占总效应的8.64%（95%CI：2.04-16.00%）。
结论：BRI与抑郁症呈正相关，AIP扮演了中介的角色。这项研究为内脏肥胖与抑郁症的关系机制提供了新的视角。管理内脏脂肪和监测AIP水平可能有助于缓解抑郁症。
方法：这项研究包括2005-2018年全国健康和营养调查的13,123名参与者。内脏肥胖用身体圆度指数(BRI)测量，而抑郁症用患者健康问卷-9进行评估。AIP用作脂质紊乱的标志物。为了调查BRI与抑郁症之间的关系，多元逻辑回归，受限制的三次样条模型，亚组分析，并使用交互测试。此外,本研究进行了中介分析,以探讨AIP在BRI对抑郁的中介效应中的作用.
结果：BRI与抑郁症呈正线性相关。在控制所有协变量后，与BRI最低(Q1)组相比,BRI最高(Q4)组的抑郁症OR为1.42(95%CI:1.12~1.82).此外，AIP部分介导了BRI与抑郁症之间的关联，约占总效应的8.64%（95%CI：2.04-16.00%）。
结论：BRI与抑郁症呈正相关，AIP扮演了中介的角色。这项研究为内脏肥胖与抑郁症的关系机制提供了新的视角。管理内脏脂肪和监测AIP水平可能有助于缓解抑郁症。
