METHODS: This study included 13,123 participants from the 2005-2018 National Health and Nutrition Examination Survey. Visceral obesity was measured with the Body Roundness Index (BRI), while depression was evaluated with the Patient Health Questionnaire-9. The AIP served as a marker for lipid disorders. To investigate the association between the BRI and depression, multivariate logistic regressions, restricted cubic spline models, subgroup analyses, and interaction tests were used. Additionally, a mediation analysis was conducted to explore the role of AIP in mediating the effect of BRI on depression.
RESULTS: There was a positive linear correlation between the BRI and depression. After controlling for all covariates, individuals in the highest BRI (Q4) group had an OR of 1.42 for depression (95% CI: 1.12-1.82) in comparison with individuals in the lowest BRI (Q1) group. Moreover, the AIP partially mediated the association between the BRI and depression, accounting for approximately 8.64% (95% CI: 2.04-16.00%) of the total effect.
CONCLUSIONS: The BRI was positively associated with depression, with the AIP playing a mediating role. This study provides a novel perspective on the mechanism that connects visceral obesity to depression. Managing visceral fat and monitoring AIP levels may contribute to alleviating depression.
方法:这项研究包括2005-2018年全国健康和营养调查的13,123名参与者。内脏肥胖用身体圆度指数(BRI)测量,而抑郁症用患者健康问卷-9进行评估。AIP用作脂质紊乱的标志物。为了调查BRI与抑郁症之间的关系,多元逻辑回归,受限制的三次样条模型,亚组分析,并使用交互测试。此外,本研究进行了中介分析,以探讨AIP在BRI对抑郁的中介效应中的作用.
结果:BRI与抑郁症呈正线性相关。在控制所有协变量后,与BRI最低(Q1)组相比,BRI最高(Q4)组的抑郁症OR为1.42(95%CI:1.12~1.82).此外,AIP部分介导了BRI与抑郁症之间的关联,约占总效应的8.64%(95%CI:2.04-16.00%)。
结论:BRI与抑郁症呈正相关,AIP扮演了中介的角色。这项研究为内脏肥胖与抑郁症的关系机制提供了新的视角。管理内脏脂肪和监测AIP水平可能有助于缓解抑郁症。