PDF(Pubmed)
Abstract：
The silencing regulatory factor 2-like protein 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+) dependent deacetylase located primarily in the mitochondria. This protein plays an important role in oxidative stress, energy metabolism, and autophagy in multicellular organisms. Autophagy (macroautophagy) is primarily a cytoprotective mechanism necessary for intracellular homeostasis and the synthesis, degradation, and recycling of cellular products. Autophagy can influence the progression of several neural, cardiac, hepatic, and renal diseases and can also contribute to the development of fibrosis, diabetes, and many types of cancer. Recent studies have shown that SIRT3 has an important role in regulating autophagy. Therefore in this study, we aimed to perform a literature review to summarize the role of SIRT3 in the regulation of cellular autophagy. The findings of this study could be used to identify new drug targets for SIRT3-related diseases. Methods: A comprehensive literature review of the mechanism involved behind SIRT3 and autophagy-related diseases was performed. Relevant literature published in Pubmed and Web of Science up to July 2023 was identified using the keywords \"silencing regulatory factor 2-like protein 3\", \"SIRT3\" and \"autophagy\".
摘要：
沉默调节因子2样蛋白3(SIRT3)是主要位于线粒体中的烟酰胺腺嘌呤二核苷酸(NAD+)依赖性脱乙酰酶。这种蛋白质在氧化应激中起重要作用，能量代谢，和多细胞生物中的自噬。自噬（巨自噬）主要是细胞内稳态和合成所必需的细胞保护机制，降解，和细胞产品的回收。自噬可以影响几种神经的进展，心脏,肝，和肾脏疾病，也可以促进纤维化的发展，糖尿病,和许多类型的癌症。最近的研究表明SIRT3在调节自噬中具有重要作用。因此，在这项研究中，我们旨在进行文献综述,总结SIRT3在细胞自噬调控中的作用.这项研究的结果可用于确定SIRT3相关疾病的新药物靶标。方法：对SIRT3和自噬相关疾病的机制进行了全面的文献综述。截至2023年7月，在Pubmed和WebofScience上发表的相关文献使用关键词“沉默调节因子2样蛋白3”进行了鉴定，\"SIRT3\"和\"自噬\"。
