PDF(Pubmed)
Abstract：
BACKGROUND: Legionella pneumonia is one of the most severe types of atypical pneumonia, impairing multiple organ systems, posing a threat to life. Diagnosing Legionella pneumonia is challenging due to difficulties in culturing the bacteria and limitations in immunoassay sensitivity and specificity.
METHODS: This paper reports a rare case of sepsis caused by combined infection with Legionella pneumophila and Fusobacterium necrophorum, leading to respiratory failure, acute kidney injury, acute liver injury, myocardial damage, and electrolyte disorders. In addition, we systematically reviewed literature on patients with combined Legionella infections, analyzing their clinical features, laboratory results and diagnosis.
CONCLUSIONS: For pathogens that require prolonged incubation periods and are less sensitive to conventional culturing methods, metagenomic next-generation sequencing (mNGS) can be a powerful supplement to pathogen screening and plays a significant role in the auxiliary diagnosis of complex infectious diseases.
METHODS: This paper reports a rare case of sepsis caused by combined infection with Legionella pneumophila and Fusobacterium necrophorum, leading to respiratory failure, acute kidney injury, acute liver injury, myocardial damage, and electrolyte disorders. In addition, we systematically reviewed literature on patients with combined Legionella infections, analyzing their clinical features, laboratory results and diagnosis.
CONCLUSIONS: For pathogens that require prolonged incubation periods and are less sensitive to conventional culturing methods, metagenomic next-generation sequencing (mNGS) can be a powerful supplement to pathogen screening and plays a significant role in the auxiliary diagnosis of complex infectious diseases.
摘要：
背景：军团菌肺炎是非典型肺炎中最严重的类型之一，损害多器官系统，对生命构成威胁.由于培养细菌的困难以及免疫测定灵敏度和特异性的限制,军团菌肺炎的诊断具有挑战性。
方法：本文报道一例罕见的由嗜肺军团菌和坏死梭菌联合感染引起的脓毒症,导致呼吸衰竭,急性肾损伤，急性肝损伤，心肌损伤,和电解质紊乱。此外,我们系统回顾了军团菌联合感染患者的文献，分析他们的临床特征，实验室结果和诊断。
结论：对于需要延长潜伏期且对常规培养方法不太敏感的病原体，宏基因组下一代测序（mNGS）可以作为病原体筛查的有力补充，在复杂传染病的辅助诊断中起着重要作用。
方法：本文报道一例罕见的由嗜肺军团菌和坏死梭菌联合感染引起的脓毒症,导致呼吸衰竭,急性肾损伤，急性肝损伤，心肌损伤,和电解质紊乱。此外,我们系统回顾了军团菌联合感染患者的文献，分析他们的临床特征，实验室结果和诊断。
结论：对于需要延长潜伏期且对常规培养方法不太敏感的病原体，宏基因组下一代测序（mNGS）可以作为病原体筛查的有力补充，在复杂传染病的辅助诊断中起着重要作用。
