PDF(Pubmed)
Abstract：
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women that is associated with an increased risk of anxiety and depression and with a lower health-related quality of life (HRQoL). PCOS is closely associated with obesity, which per se can lead to symptoms of anxiety and depression and lower HRQoL. The first-line treatment for PCOS is weight loss through lifestyle intervention, which has been shown to improve all symptoms of the syndrome. The aim of this study was to investigate symptoms of anxiety and depression and HRQoL in women with severe obesity (BMI ≥ 35) with and without PCOS, and to evaluate the effect of a one-year structured weight loss intervention. A total of 246 women with severe obesity (PCOS n = 63, non-PCOS n = 183) were included. The comprehensive psychopathological rating scale self-rating scale for affective symptoms (CPRS-S-A) and the short form-36 (SF-36) were used to assess symptoms of anxiety and depression and HRQoL. In total 72 women of the 246 women with severe obesity completed a one-year weight loss programme and were followed up and compared with baseline data. In women with severe obesity, there were no differences in symptoms of anxiety and depression and HRQoL between women with and without PCOS at baseline. Clinically relevant anxiety symptoms were present in 71.3% (PCOS) and 65.6% (non-PCOS), and depression symptoms were present in 56.4% (PCOS) and 52.2% (non-PCOS). Significant weight loss improved physical HRQoL in all women, but reduced symptoms of anxiety and depression only in women without PCOS. There were no differences when comparing the changes between the groups. Women with severe obesity are severely affected by symptoms of anxiety and depression, independent of PCOS. Weight loss improved symptoms of anxiety and depression in women without PCOS, but there were no differences between groups in change from baseline to follow-up.Trial registration number: Clinical trial.gov: NCT01319162, March 18, 2011. Date of registration and enrolment of the first subject September 2011.
摘要：
多囊卵巢综合征（PCOS）是女性常见的内分泌疾病，与焦虑和抑郁的风险增加以及与健康相关的生活质量（HRQoL）降低有关。PCOS与肥胖密切相关,其本身可导致焦虑和抑郁症状和较低的HRQoL。PCOS的一线治疗是通过生活方式干预来减轻体重，已被证明可以改善该综合征的所有症状。这项研究的目的是调查患有和不患有PCOS的重度肥胖（BMI≥35）女性的焦虑和抑郁症状以及HRQoL。并评估为期一年的结构性减肥干预的效果。共纳入246名重度肥胖妇女（PCOSn=63，非PCOSn=183）。使用综合心理病理学评定量表（CPRS-S-A）和简短形式-36（SF-36）评估焦虑和抑郁症状以及HRQoL。在246名重度肥胖妇女中，共有72名妇女完成了为期一年的减肥计划，并进行了随访并与基线数据进行了比较。在患有严重肥胖的女性中，基线时,有和没有PCOS的女性焦虑,抑郁症状和HRQoL无差异.临床相关的焦虑症状在71.3%（PCOS）和65.6%（非PCOS）存在，56.4%(PCOS)和52.2%(非PCOS)存在抑郁症状。显著的体重减轻改善了所有女性的身体HRQoL，但仅在没有PCOS的女性中减少了焦虑和抑郁症状。比较组间变化时没有差异。患有严重肥胖的妇女受到焦虑和抑郁症状的严重影响，独立于PCOS。体重减轻改善了没有PCOS的女性的焦虑和抑郁症状，但两组之间从基线到随访的变化无差异.试验登记号：临床试验.gov：NCT01319162，2011年3月18日。2011年9月第一个科目的注册和注册日期。
