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Abstract：
To investigate biomarkers of intra-ocular pressure (IOP) decrease after cataract surgery with trabecular washout in pseudo-exfoliative (PEX) glaucoma. A single-center observational prospective study in PEX glaucoma patients undergoing cataract surgery with trabecular washout (Goniowash) was performed from 2018 to 2021. Age, gender, visual acuity, IOP, endothelial cell count, central corneal thickness, medications, were collected over 16-month follow-up. Multivariable binomial regression models were implemented. 54 eyes (35 subjects) were included. Mean preoperative IOP (IOPBL) was 15.9 ± 3.5 mmHg. Postoperative IOP reduction was significant at 1-month and throughout follow-up (p < 0.01, respectively). IOPBL was a predictive biomarker inversely correlated to IOP decrease throughout follow-up (p < 0.001). At 1 and 12 months of follow-up, IOP decrease concerned 31 (57.4%) and 34 (63.0%) eyes with an average IOP decrease of 17.5% (from 17.6 ± 3.1 to 14.3 ± 2.2 mmHg) and 23.0% (from 17.7 ± 2.8 to 13.5 ± 2.6 mmHg), respectively. Performance (AUC) of IOPBL was 0.85 and 0.94 (p < 0.0001, respectively), with IOPBL threshold ≥ 15 mmHg for 82.1% and 96.8% sensitivity, 84.2% and 75.0% specificity, 1.84 and 3.91 IOP decrease odds-ratio, respectively. All PEX glaucoma patients with IOPBL greater than or equal to the average general population IOP were likely to achieve a significant sustainable postoperative IOP decrease.
摘要：
探讨假性剥脱性（PEX）青光眼白内障手术伴小梁冲洗后眼压（IOP）降低的生物标志物。2018年至2021年，在接受小梁冲洗（Goniowash）白内障手术的PEX青光眼患者中进行了一项单中心观察性前瞻性研究。年龄,性别,视敏度,IOP,内皮细胞计数,中央角膜厚度,药物,在16个月的随访中收集。实施多变量二项回归模型。包括54只眼（35名受试者）。术前平均IOP（IOPBL）为15.9±3.5mmHg。术后1个月和整个随访期间IOP显著降低(分别为p<0.01)。IOPBL是在整个随访期间与IOP降低呈负相关的预测性生物标志物(p<0.001)。在随访1个月和12个月时，眼压下降涉及31只(57.4%)和34只(63.0%)眼，平均眼压下降17.5%(从17.6±3.1到14.3±2.2mmHg)和23.0%(从17.7±2.8到13.5±2.6mmHg)，分别。IOPBL的性能（AUC）分别为0.85和0.94（p<0.0001），IOPBL阈值≥15mmHg，灵敏度为82.1%和96.8%，84.2%和75.0%的特异性，1.84和3.91眼压降低比值比，分别。IOPBL大于或等于普通人群平均IOP的所有PEX青光眼患者可能实现术后IOP的显着可持续降低。
