Abstract：
This research focuses on the challenges of efficiently constructing drug carriers and evaluating their dynamic release in vitro simulation. By using pickering emulsion and layer-by-layer self-assembly methods. The microcapsules had tea tree oil as the core material, SiO2 nanoparticles as stabilizers, and chitosan and hyaluronic acid as shell materials. The microencapsulation mechanism, as well as the effects of core-shell mass ratio and stirring, were discussed. Specifically, a dynamic circulation simulation microchannel system was designed and manufactured based on 3D printing technology. In this simulation system, the release rate of microcapsules is accelerated and the trend changes, with its behavior aligning with the Boltzmann model. The study demonstrates the advantages of self-assembled inorganic-organic drug-loaded microcapsules in terms of controllable fabrication and ease of functional modification, and shows the potential of 3D printed cyclic microchannel systems in terms of operability and simulation fidelity in drug and physiological analysis.
摘要：
本研究的重点是有效构建药物载体并在体外模拟中评估其动态释放的挑战。通过采用酸洗乳液和层层自组装的方法。微胶囊以茶树油为核心材料，SiO2纳米粒子作为稳定剂，壳聚糖和透明质酸作为外壳材料。微囊化机理,以及核壳质量比和搅拌的影响，进行了讨论。具体来说,设计并制作了基于3D打印技术的动态循环模拟微通道系统。在这个仿真系统中,微胶囊的释放速度加快，趋势发生变化，其行为与玻尔兹曼模型一致。该研究证明了自组装的无机-有机载药微胶囊在可控制备和易于功能修饰方面的优势。并显示了3D打印循环微通道系统在药物和生理分析中的可操作性和模拟保真度方面的潜力。
