Abstract：
BACKGROUND: The aim of the study was to determine the prevalence of metamorphopsia following rhegmatogenous retinal detachment (RRD) surgery, as well as associated predictive factors.
METHODS: A total of 107 eyes successfully operated for RRD underwent metamorphopsia severity assessment using M-CHARTS, and foveal microstructure analysis by spectral domain optical coherence tomography, at 1 and 6 months postoperatively. Univariate and multivariate logistic regression rendered evaluation of preoperative risk factors. The correlation between metamorphopsia score and outer retinal layer (ORL) integrity was investigated and preoperative risk factors evaluated.
RESULTS: The prevalence of postoperative metamorphopsia decreased from 51.4 to 29.9% and the median metamorphopsia score significantly improved (0.5, 95% CI: 0.3; 0.9, to 0.2, 95% CI: 0; 0.5, p < 0.001) from 1 to 6 months, respectively. Preoperative macular detachment was the only predictor found (OR 11.0, 95% CI: 3.1; 39.4, p < 0.001). Metamorphopsia severity was significantly associated with outer nuclear layer thickness and the status of the ellipsoid and cone interdigitation zones. One-month M-CHARTS had 81% sensitivity and 87% specificity in predicting full metamorphopsia recovery at 6 months (0.45 cut-off score).
CONCLUSIONS: The prevalence of metamorphopsia decreased in parallel to ORL restoration, thus demonstrating the etiological role of photoreceptor-level morphological changes. M-CHARTS allowed for monitoring and predicting metamorphopsia recovery after RRD.
METHODS: A total of 107 eyes successfully operated for RRD underwent metamorphopsia severity assessment using M-CHARTS, and foveal microstructure analysis by spectral domain optical coherence tomography, at 1 and 6 months postoperatively. Univariate and multivariate logistic regression rendered evaluation of preoperative risk factors. The correlation between metamorphopsia score and outer retinal layer (ORL) integrity was investigated and preoperative risk factors evaluated.
RESULTS: The prevalence of postoperative metamorphopsia decreased from 51.4 to 29.9% and the median metamorphopsia score significantly improved (0.5, 95% CI: 0.3; 0.9, to 0.2, 95% CI: 0; 0.5, p < 0.001) from 1 to 6 months, respectively. Preoperative macular detachment was the only predictor found (OR 11.0, 95% CI: 3.1; 39.4, p < 0.001). Metamorphopsia severity was significantly associated with outer nuclear layer thickness and the status of the ellipsoid and cone interdigitation zones. One-month M-CHARTS had 81% sensitivity and 87% specificity in predicting full metamorphopsia recovery at 6 months (0.45 cut-off score).
CONCLUSIONS: The prevalence of metamorphopsia decreased in parallel to ORL restoration, thus demonstrating the etiological role of photoreceptor-level morphological changes. M-CHARTS allowed for monitoring and predicting metamorphopsia recovery after RRD.
摘要：
背景：为了确定孔源性视网膜脱离（RRD）手术后变形的患病率，以及相关的预测因素。
方法：使用M-CHARTS对成功进行RRD手术的107只眼进行了变形视严重程度评估，和通过光谱域光学相干层析成像进行中央凹微结构分析，术后1个月和6个月。单变量和多变量逻辑回归对术前危险因素进行评估。研究了视网膜外层（ORL）完整性与变形性评分之间的相关性，评估术前危险因素。
结果：术后变形的患病率从51.4%降至29.9%，中位变形评分显著改善（0.5，95%CI[0.3;0.9]至0.2，95%CI[0;0.5]，p<0.001)从1t到6个月，分别。术前黄斑脱离是唯一的预测因子(OR11.0,95%CI[3.1;39.4],p<0.001)。变形严重程度与外核层厚度显着相关，和椭球的状态，和圆锥交错区。一个月M-CHARTS在预测6个月时完全变形恢复方面具有81％的敏感性和87％的特异性（0.45分）。
结论：与ORL恢复平行，变形的患病率降低，从而证明了光感受器水平形态变化的病因学作用。M-CHARTS允许监测和预测RRD后的变形虫恢复。
方法：使用M-CHARTS对成功进行RRD手术的107只眼进行了变形视严重程度评估，和通过光谱域光学相干层析成像进行中央凹微结构分析，术后1个月和6个月。单变量和多变量逻辑回归对术前危险因素进行评估。研究了视网膜外层（ORL）完整性与变形性评分之间的相关性，评估术前危险因素。
结果：术后变形的患病率从51.4%降至29.9%，中位变形评分显著改善（0.5，95%CI[0.3;0.9]至0.2，95%CI[0;0.5]，p<0.001)从1t到6个月，分别。术前黄斑脱离是唯一的预测因子(OR11.0,95%CI[3.1;39.4],p<0.001)。变形严重程度与外核层厚度显着相关，和椭球的状态，和圆锥交错区。一个月M-CHARTS在预测6个月时完全变形恢复方面具有81％的敏感性和87％的特异性（0.45分）。
结论：与ORL恢复平行，变形的患病率降低，从而证明了光感受器水平形态变化的病因学作用。M-CHARTS允许监测和预测RRD后的变形虫恢复。
