METHODS: Ovid MEDLINE, Embase, CENTRAL, Web of Science, ClinicalTrials.gov and European Trials Register were searched for eligible studies investigating the impact of comorbidity on various postoperative outcomes of patients aged ≥65. Findings were narratively reported.
RESULTS: The review identified 40 studies with a total population of 59,612 patients, using eight different methods of comorbidity assessment. The most used was Charlson Comorbidity Index (60 % of studies) and presence of specific comorbid conditions (38 %). No study provided rationale for the choice of specific comorbidity measure. Most of the included studies reported short-term results (75 %), such as postoperative complications (43 %) and mortality (18 %) as main clinical endpoint. The results were inconsistent across the studies.
CONCLUSIONS: There is still no consensus regarding the choice of comorbidity measures and their role in postoperative outcome prediction. Further efforts are needed to develop new, well-designed, more effective comorbidity assessments tools.
方法:OvidMEDLINE,Embase,中部,WebofScience,在ClinicalTrials.gov和EuropeanTrialsRegister中搜索了符合条件的研究,以调查合并症对65岁以上患者的各种术后结局的影响。对调查结果进行了叙述性报道。
结果:该综述确定了40项研究,共有59,612名患者,使用八种不同的共病评估方法。使用最多的是Charlson合并症指数(60%的研究)和特定合并症的存在(38%)。没有研究提供选择特定合并症措施的理由。大多数纳入的研究报告了短期结果(75%),如术后并发症(43%)和死亡率(18%)作为主要临床终点。研究结果不一致。
结论:关于合并症措施的选择及其在术后预后预测中的作用仍未达成共识。还需要进一步努力开发新的,精心设计,更有效的合并症评估工具。