PDF(Pubmed)
Abstract：
Women living with human immunodeficiency virus are at an increased risk of developing cancers related to human papillomavirus (HPV). Thus, it is important to combine clinical assessments, serological screening, and HPV data for planning prevention policies. This study aimed to identify HPV and its specific types in the cervical, anal, and oral mucosa of HIV-seropositive women, associating it with viral load and lymphocyte count. Sociodemographic characteristics, health data (CD4+ and CD8+ T cell counts and viral load), and biological samples (cervical, anal, and oral) were collected from 86 HIV-positive women undergoing antiretroviral therapy. Data were classified according to the presence or absence of HPV-DNA, HPV-DNA presence at one or more anatomic sites, and level of oncogenic risk, considering low- and high-risk oncogenic HPV-DNA groups. The presence of HPV in the cervicovaginal site was 65.9%, 63.8% in anal canal, and 4.2% in oral mucosa. A viral load ≥75 HIV copies/mL was associated with the presence of HPV-DNA. There was an association between viral load and the low-risk HPV or high-risk HPV groups. We found a high prevalence of HPV infection in HIV-seropositive women, particularly in the cervical and anal mucosa, with viral load ≥75 HIV copies/mL being associated with HPV-DNA presence.
摘要：
患有人类免疫缺陷病毒的妇女患与人乳头瘤病毒（HPV）相关的癌症的风险增加。因此，结合临床评估很重要，血清学筛查,和HPV数据用于规划预防政策。本研究旨在鉴定宫颈HPV及其特定类型,肛门,和HIV血清阳性妇女的口腔粘膜，将其与病毒载量和淋巴细胞计数相关联。社会人口统计学特征，健康数据（CD4+和CD8+T细胞计数和病毒载量），和生物样本(宫颈，肛门,和口服）是从接受抗逆转录病毒治疗的86名HIV阳性妇女中收集的。根据HPV-DNA的存在或不存在对数据进行分类。HPV-DNA存在于一个或多个解剖部位，和致癌风险水平，考虑低危和高危致癌HPV-DNA组。宫颈阴道部位HPV的存在率为65.9％，63.8%在肛管，在口腔粘膜中占4.2%。病毒载量≥75HIV拷贝/mL与HPV-DNA的存在相关。病毒载量与低危HPV或高危HPV组之间存在关联。我们发现在HIV血清阳性的女性中HPV感染率很高，特别是在宫颈和肛门粘膜，病毒载量≥75HIV拷贝/mL与HPV-DNA存在相关。
