PDF(Pubmed)
Abstract：
Abomasal ulcers are recognized in sheep of all ages, but research regarding therapeutic interventions is limited. Proton Pump Inhibitors (PPIs) such as pantoprazole, are clinically used with a paucity of evidence regarding efficacy in mature sheep. Intravenous and subcutaneously administered pantoprazole dosed at 1.0 mg/kg in adult sheep will increase the pH of abomasal fluid compared to pre-administration baseline. The objectives were to assess the effect of pantoprazole, after single and multiple administration, on abomasal fluid pH in adult sheep. A third objective was to describe the pharmacokinetic parameters of IV and SC pantoprazole. Four clinically healthy adult Southdown ewes previously fitted with a gastrostomy tube in the abomasum were utilized in this randomized, 2-way cross-over trial. Ewes received pantoprazole (1.0 mg/kg) as a single and 3-dose regimen (every 24 hours). After a 10 day washout period the reverse treatment was applied. Blood for analysis of pantoprazole concentration was collected intermittently for 24 hours, and abomasal fluid pH was measured at intervals for a 96-hour period. The pH of the abomasal fluid was higher in pantoprazole treatments for up to 24 hours after dosing. Following intravenous administration of pantoprazole to study ewes, elimination half-life, volume of distribution, and clearance of pantoprazole was estimated as 3.29 hours, 0.35 L/kg, and 65.26 mL/hr/kg respectively. After subcutaneous dosing, maximum concentration, time to maximum concentration, half-life of elimination, and volume of distribution, were estimated as 2604 ng/mL, 0.55 hours, 2.48 hours, and 0.37 L/kg. Additionally, the bioavailability was estimated as 83.33%. Pantoprazole administered IV or SC may be useful for treatment or prevention of abomasal ulcers in adult sheep.
摘要：
在所有年龄的绵羊中都可以识别出口腔溃疡，但是关于治疗干预的研究是有限的。质子泵抑制剂（PPI），如泮托拉唑，在临床上很少有关于成熟绵羊功效的证据。与给药前基线相比,在成年绵羊中以1.0mg/kg的剂量静脉内和皮下给药泮托拉唑将增加恶鼻液的pH。目的是评估泮托拉唑的效果，在单次和多次给药后，对成年绵羊恶鼻液pH值的影响。第三个目的是描述IV和SC泮托拉唑的药代动力学参数。在此随机分组中，使用了四只临床健康的成年Southdown母羊，这些母羊先前在皱胃中装有胃造口术管，双向交叉试验。Ewes接受泮托拉唑（1.0mg/kg）作为单剂量和3剂量方案（每24小时）。在10天的清除期后,应用反向处理。用于分析泮托拉唑浓度的血液间歇收集24小时，每隔96小时测量一次鼻部液体的pH值。在泮托拉唑治疗中,恶鼻液的pH在给药后长达24小时内更高。在静脉注射泮托拉唑以研究母羊后，消除半衰期，分配量，泮托拉唑的清除率估计为3.29小时，0.35L/kg,和65.26mL/hr/kg。皮下给药后，最大浓度,达到最大浓度的时间，消除的半衰期，和分配量，估计为2604纳克/毫升，0.55小时,2.48小时,和0.37L/kg。此外,生物利用度估计为83.33%.IV或SC给药的泮托拉唑可用于治疗或预防成年绵羊的恶鼻溃疡。
