Abstract：
Sophora flavescens has been widely used in traditional Chinese medicine for over 1700 years. This plant is known for its heat-clearing, damp-drying, insecticidal, and diuretic properties. Phytochemical research has identified prenylated flavonoids as a unique class of bioactive compounds in S. flavescens. Recent pharmacological studies reveal that the prenylated flavonoids from S. flavescens (PFS) exhibit potent antitumor, anti-inflammatory, and glycolipid metabolism-regulating activities, offering significant therapeutic benefits for various diseases. However, the pharmacokinetics and toxicological profiles of PFS have not been systematically studied. Despite the diverse biological effects of prenylated flavonoid compounds against similar diseases, their structure-activity relationship is not yet fully understood. This review aims to summarize the latest findings regarding the chemical composition, drug metabolism, pharmacological properties, toxicity, and structure-activity relationship of prenylated flavonoids from S. flavescens. It seeks to highlight their potential for clinical use and suggest directions for future related studies.
摘要：
苦参在中药中的广泛应用已有1700多年。这种植物以其清热而闻名，湿干,杀虫,和利尿特性。植物化学研究已经确定异戊烯化类黄酮是苦参中独特的一类生物活性化合物。近年来的药理研究表明,苦参异戊烯化黄酮类化合物(PFS)具有较强的抗肿瘤作用,抗炎,和糖脂代谢调节活动，为各种疾病提供显著的治疗益处。然而,PFS的药代动力学和毒理学特征尚未得到系统研究。尽管异戊烯化类黄酮化合物对类似疾病的生物效应不同，它们的结构-活动关系尚未完全理解。这篇综述旨在总结有关化学成分的最新发现，药物代谢，药理学性质，毒性,苦参异戊烯黄酮的构效关系。它旨在强调其临床应用的潜力，并为未来的相关研究提供方向。
