PDF(Pubmed)
Abstract：
UNASSIGNED: Peak Expiratory Flow (PEF) is associated with a variety of adverse health outcomes in older adults; however, the relationship between PEF and frailty remains uncertain, and this study investigated the relationship between PEF and frailty within an olderly Asian demographic.
UNASSIGNED: Data were sourced from the Chinese Health and Retirement Longitudinal Study (CHARLS). Individuals in the study, all 60 years or older, underwent baseline PEF assessments quantified as standardized residual (SR) percentile values. The evaluation of frailty was conducted based on the criteria established by Fried. Participants without frailty at the outset were tracked over a four-year period, during which the relationships between PEF and frailty were examined through logistic regression and discrete-time Cox regression analyses.
UNASSIGNED: Among 5,060 participants, cross-sectional analysis revealed that the prevalence of frailty was 2-3 times higher in the lower 10-49th and < 10th SR percentile groups compared to the 80-100th SR percentile group. The longitudinal study corroborated these results, showing an adjusted hazard ratio (HR) of 2.01 (95% CI, 1.15-3.51) for PEF SR percentiles below the 10th, in contrast to those between the 80th and 100th percentiles.
UNASSIGNED: PEF independently predicts and determines frailty in older adults. Declines in PEF greater than expected are associated with the development of frailty. Subsequent studies are encouraged to delve deeper into the connection between respiratory function and frailty in diverse contexts.
UNASSIGNED: Data were sourced from the Chinese Health and Retirement Longitudinal Study (CHARLS). Individuals in the study, all 60 years or older, underwent baseline PEF assessments quantified as standardized residual (SR) percentile values. The evaluation of frailty was conducted based on the criteria established by Fried. Participants without frailty at the outset were tracked over a four-year period, during which the relationships between PEF and frailty were examined through logistic regression and discrete-time Cox regression analyses.
UNASSIGNED: Among 5,060 participants, cross-sectional analysis revealed that the prevalence of frailty was 2-3 times higher in the lower 10-49th and < 10th SR percentile groups compared to the 80-100th SR percentile group. The longitudinal study corroborated these results, showing an adjusted hazard ratio (HR) of 2.01 (95% CI, 1.15-3.51) for PEF SR percentiles below the 10th, in contrast to those between the 80th and 100th percentiles.
UNASSIGNED: PEF independently predicts and determines frailty in older adults. Declines in PEF greater than expected are associated with the development of frailty. Subsequent studies are encouraged to delve deeper into the connection between respiratory function and frailty in diverse contexts.
摘要：
■峰值呼气流量（PEF）与老年人的各种不良健康结果有关；然而，PEF和脆弱之间的关系仍然不确定，这项研究调查了亚洲老年人群中PEF与虚弱之间的关系。
■数据来自中国健康与退休纵向研究（CHARLS）。研究中的个人，所有60岁或以上的人，接受基线PEF评估，量化为标准化残留（SR）百分位值。根据Fried建立的标准进行虚弱的评估。一开始没有弱点的参与者被跟踪了四年，在此期间,我们通过logistic回归和离散时间Cox回归分析来检验PEF与虚弱之间的关系.
■在5,060名参与者中，横断面分析显示，与第80-100个SR百分位数组相比，第10-49个和<10个SR百分位数组的虚弱患病率高2-3倍。纵向研究证实了这些结果，显示PEFSR百分位数低于10的2.01（95％CI，1.15-3.51）的调整后危险比（HR），与第80个百分位数和第100个百分位数之间的百分位数相反。
■PEF独立预测和确定老年人的虚弱。PEF的下降大于预期与脆弱的发展有关。鼓励后续研究更深入地研究不同背景下呼吸功能与虚弱之间的联系。
■数据来自中国健康与退休纵向研究（CHARLS）。研究中的个人，所有60岁或以上的人，接受基线PEF评估，量化为标准化残留（SR）百分位值。根据Fried建立的标准进行虚弱的评估。一开始没有弱点的参与者被跟踪了四年，在此期间,我们通过logistic回归和离散时间Cox回归分析来检验PEF与虚弱之间的关系.
■在5,060名参与者中，横断面分析显示，与第80-100个SR百分位数组相比，第10-49个和<10个SR百分位数组的虚弱患病率高2-3倍。纵向研究证实了这些结果，显示PEFSR百分位数低于10的2.01（95％CI，1.15-3.51）的调整后危险比（HR），与第80个百分位数和第100个百分位数之间的百分位数相反。
■PEF独立预测和确定老年人的虚弱。PEF的下降大于预期与脆弱的发展有关。鼓励后续研究更深入地研究不同背景下呼吸功能与虚弱之间的联系。
