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Abstract：
Globally, cardiovascular disease (CVD) remains the leading cause of mortality and disability, with hypertension being the single most important modifiable risk factor. Hypertension is responsible for about 18% of global deaths from CVD, of which African regions are disproportionately affected, especially sub-Saharan Africa. This study assessed the burden of major CVD subtypes attributable to hypertension in Nigeria.
The population attributable fractions (PAF) for myocardial infarction, all strokes, ischaemic stroke and intracerebral haemorrhagic stroke attributable to hypertension in Nigeria were calculated using published results from the INTERHEART and INTERSTROKE studies and prevalence estimates of hypertension in Nigeria. PAF estimates were obtained for age, sex, and geopolitical zones.
Overall, hypertension contributed to 13.2% of all myocardial infarctions and 24.6% of all strokes, including 21.6% of all ischaemic strokes and 33.1% of all intracerebral haemorrhagic strokes. Among men aged ≤55 years, the PAF for myocardial infarction ranged from 11.7% (North-West) to 14.6% (South-East), while in older men, it spanned 9.2% (North-West) to 11.9% (South-East). Among women aged ≤65 years, PAF varied from 18.6% (South-South) to 20.8% (South-East and North-Central), and among women aged >65 years, it ranged from 10.4% (South-South) to 12.7% (South-East).
Hypertension is a key contributor to the burden of CVD in Nigeria. Understanding the burden of hypertension in the Nigerian population overall and key subgroups is crucial to developing and implementing contextualised health policies to reduce the burden of CVD. Public health interventions and policies centred on hypertension will play a critical role in potentially alleviating the burden of cardiovascular diseases (CVD) in Nigeria.
The population attributable fractions (PAF) for myocardial infarction, all strokes, ischaemic stroke and intracerebral haemorrhagic stroke attributable to hypertension in Nigeria were calculated using published results from the INTERHEART and INTERSTROKE studies and prevalence estimates of hypertension in Nigeria. PAF estimates were obtained for age, sex, and geopolitical zones.
Overall, hypertension contributed to 13.2% of all myocardial infarctions and 24.6% of all strokes, including 21.6% of all ischaemic strokes and 33.1% of all intracerebral haemorrhagic strokes. Among men aged ≤55 years, the PAF for myocardial infarction ranged from 11.7% (North-West) to 14.6% (South-East), while in older men, it spanned 9.2% (North-West) to 11.9% (South-East). Among women aged ≤65 years, PAF varied from 18.6% (South-South) to 20.8% (South-East and North-Central), and among women aged >65 years, it ranged from 10.4% (South-South) to 12.7% (South-East).
Hypertension is a key contributor to the burden of CVD in Nigeria. Understanding the burden of hypertension in the Nigerian population overall and key subgroups is crucial to developing and implementing contextualised health policies to reduce the burden of CVD. Public health interventions and policies centred on hypertension will play a critical role in potentially alleviating the burden of cardiovascular diseases (CVD) in Nigeria.
摘要：
■全球，心血管疾病（CVD）仍然是死亡和残疾的主要原因，高血压是唯一最重要的可改变的危险因素。高血压是造成全球约18%的心血管疾病死亡的原因，其中非洲地区受到不成比例的影响，尤其是撒哈拉以南非洲。这项研究评估了尼日利亚高血压引起的主要CVD亚型的负担。
■心肌梗死的群体归因分数（PAF），所有笔划,使用INTERHEART和INTERSTROKE研究的已发表结果以及尼日利亚高血压的患病率估计,计算了尼日利亚高血压导致的缺血性卒中和脑出血卒中.PAF估计是根据年龄获得的，性别,和地缘政治区。
■总的来说，高血压导致了13.2%的心肌梗死和24.6%的中风,包括所有缺血性中风的21.6％和所有脑出血中风的33.1％。在≤55岁的男性中，心肌梗死的PAF范围从11.7%（西北）到14.6%（东南），而在年长的男人中，它跨越9.2％（西北）至11.9％（东南）。在≤65岁的女性中，PAF从18.6%(南-南)到20.8%(东南和中北部)不等,在年龄>65岁的女性中，从10.4%(南-南)到12.7%(东南)不等。
■高血压是尼日利亚心血管疾病负担的关键因素。了解尼日利亚人口总体和关键亚组的高血压负担对于制定和实施情境化卫生政策以减轻CVD负担至关重要。以高血压为中心的公共卫生干预措施和政策将在减轻尼日利亚心血管疾病（CVD）负担方面发挥关键作用。
■心肌梗死的群体归因分数（PAF），所有笔划,使用INTERHEART和INTERSTROKE研究的已发表结果以及尼日利亚高血压的患病率估计,计算了尼日利亚高血压导致的缺血性卒中和脑出血卒中.PAF估计是根据年龄获得的，性别,和地缘政治区。
■总的来说，高血压导致了13.2%的心肌梗死和24.6%的中风,包括所有缺血性中风的21.6％和所有脑出血中风的33.1％。在≤55岁的男性中，心肌梗死的PAF范围从11.7%（西北）到14.6%（东南），而在年长的男人中，它跨越9.2％（西北）至11.9％（东南）。在≤65岁的女性中，PAF从18.6%(南-南)到20.8%(东南和中北部)不等,在年龄>65岁的女性中，从10.4%(南-南)到12.7%(东南)不等。
■高血压是尼日利亚心血管疾病负担的关键因素。了解尼日利亚人口总体和关键亚组的高血压负担对于制定和实施情境化卫生政策以减轻CVD负担至关重要。以高血压为中心的公共卫生干预措施和政策将在减轻尼日利亚心血管疾病（CVD）负担方面发挥关键作用。
