PDF(Pubmed)
Abstract：
OBJECTIVE: Urinary tract infection (UTI) is the most common bacterial infection in infants. Current practice guidelines suggest a treatment duration of 7 to 14 days. Suboptimal therapy may increase the risk for recurrent UTIs leading to renal scarring and possibly chronic kidney disease. The primary objective is to evaluate the duration of therapy for UTIs and its association with the incidence of recurrent UTIs in a neonatal intensive care unit (NICU). The secondary objectives are to identify the risk factors and the most common organisms for recurrent UTIs.
METHODS: Patients were identified via the diagnosis codes for UTIs and were included if admitted to the NICU and if they received antibiotics prior to hospital discharge. Patients were divided into 2 groups: antibiotic treatment for 7 days or fewer and antibiotic treatment for greater than 7 days.
RESULTS: Eighty-six infants were included in the study. Twenty-six patients received antibiotics for 7 days or fewer, and 60 for more than 7 days. In the study, the median birth weight was 977 g and the median gestational age was 27.6 weeks. There was no significant difference in the rate of recurrent UTIs between the 2 groups (p = 0.66). However, in the subgroup analysis, the incidence was higher for patients receiving antibiotic therapy for fewer than 7 days versus 7 days (p = 0.03).
CONCLUSIONS: There was no difference in recurrence of UTI between treatment groups (≤7 days versus >7 days), and recurrence was seen in a higher percentage of patients with a urinary tract anomaly.
METHODS: Patients were identified via the diagnosis codes for UTIs and were included if admitted to the NICU and if they received antibiotics prior to hospital discharge. Patients were divided into 2 groups: antibiotic treatment for 7 days or fewer and antibiotic treatment for greater than 7 days.
RESULTS: Eighty-six infants were included in the study. Twenty-six patients received antibiotics for 7 days or fewer, and 60 for more than 7 days. In the study, the median birth weight was 977 g and the median gestational age was 27.6 weeks. There was no significant difference in the rate of recurrent UTIs between the 2 groups (p = 0.66). However, in the subgroup analysis, the incidence was higher for patients receiving antibiotic therapy for fewer than 7 days versus 7 days (p = 0.03).
CONCLUSIONS: There was no difference in recurrence of UTI between treatment groups (≤7 days versus >7 days), and recurrence was seen in a higher percentage of patients with a urinary tract anomaly.
摘要：
目的：尿路感染（UTI）是婴儿最常见的细菌感染。目前的实践指南建议治疗时间为7至14天。次优治疗可能会增加复发性尿路感染的风险，导致肾脏瘢痕形成，并可能导致慢性肾脏疾病。主要目的是评估UTI治疗的持续时间及其与新生儿重症监护病房（NICU）中复发性UTI发生率的关系。次要目标是确定复发性UTI的风险因素和最常见的生物体。
方法：患者通过UTI的诊断代码进行鉴定，如果患者进入NICU并且在出院前接受抗生素治疗，则将其纳入。患者分为两组：抗生素治疗7天或更短，抗生素治疗7天以上。
结果：研究中纳入了86名婴儿。26名患者接受抗生素治疗7天或更短，和60超过7天。在研究中,中位出生体重为977g,中位孕龄为27.6周.两组间尿路感染复发率无显著差异(p=0.66)。然而,在亚组分析中，接受抗生素治疗少于7天的患者的发病率高于7天(p=0.03).
结论：治疗组之间UTI的复发没有差异（≤7天对>7天），在尿路异常的患者中，复发的比例更高。
方法：患者通过UTI的诊断代码进行鉴定，如果患者进入NICU并且在出院前接受抗生素治疗，则将其纳入。患者分为两组：抗生素治疗7天或更短，抗生素治疗7天以上。
结果：研究中纳入了86名婴儿。26名患者接受抗生素治疗7天或更短，和60超过7天。在研究中,中位出生体重为977g,中位孕龄为27.6周.两组间尿路感染复发率无显著差异(p=0.66)。然而,在亚组分析中，接受抗生素治疗少于7天的患者的发病率高于7天(p=0.03).
结论：治疗组之间UTI的复发没有差异（≤7天对>7天），在尿路异常的患者中，复发的比例更高。
